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@ARTICLE{Cho:863920,
      author       = {Cho, Kuan-Hung and Huang, Sheng-Min and Choi, Chang-Hoon
                      and Chen, Ming-Jye and Chiang, Hsuan-Han and Buschbeck,
                      Richard P. and Farrher, Ezequiel and Shah, N. J. and
                      Garipov, Ruslan and Chang, Ching-Ping and Chang, Hsu and
                      Kuo, Li-Wei},
      title        = {{D}evelopment, integration and use of an
                      ultra-high-strength gradient system on a human-size 3 {T}
                      magnet for small animal {MRI}},
      journal      = {PLOS ONE},
      volume       = {14},
      number       = {6},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {FZJ-2019-03883},
      pages        = {e0217916 -},
      year         = {2019},
      abstract     = {This study aims to integrate an ultra-high-strength
                      gradient coil system on a clinical 3 T magnet and
                      demonstrate its preclinical imaging capabilities. Dedicated
                      phantoms were used to qualitatively and quantitatively
                      assess the performance of the gradient system. Advanced MR
                      imaging sequences, including diffusion tensor imaging (DTI)
                      and quantitative susceptibility mapping (QSM), were
                      implemented and executed on an ex vivo specimen as well as
                      in vivo rats. The DTI and QSM results on the phantom agreed
                      well with those in the literature. Furthermore, studies on
                      ex vivo specimens have demonstrated the applicability of DTI
                      and QSM on our system to probe microstructural changes in a
                      mild traumatic brain injury rat model. The feasibility of in
                      vivo rat DTI was also demonstrated. We showed that the
                      inserted ultra-high-strength gradient coil was successfully
                      integrated on a clinically used magnet. After careful tuning
                      and calibration, we verified the accuracy and quantitative
                      preclinical imaging capability of the integrated system in
                      phantom and in vivo rat brain experiments. This study can be
                      essential to establish dedicated animal MRI platform on
                      clinical MRI scanners and facilitate translational studies
                      at clinical settings.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31158259},
      UT           = {WOS:000469915700034},
      doi          = {10.1371/journal.pone.0217916},
      url          = {https://juser.fz-juelich.de/record/863920},
}