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@ARTICLE{Holm:864170,
      author       = {Holm, Stefan H. and Zhang, Zunmin and Beech, Jason P. and
                      Gompper, Gerhard and Fedosov, Dmitry A. and Tegenfeldt,
                      Jonas O.},
      title        = {l{M}icrofluidic {P}article {S}orting in {C}oncentrated
                      {E}rythrocyte {S}uspensions},
      journal      = {Physical review applied},
      volume       = {12},
      number       = {1},
      issn         = {2331-7019},
      address      = {College Park, Md. [u.a.]},
      publisher    = {American Physical Society},
      reportid     = {FZJ-2019-04036},
      pages        = {014051},
      year         = {2019},
      abstract     = {An important step in diagnostics is the isolation of
                      specific cells and microorganisms of interest from blood.
                      Since such bioparticles are often present at very low
                      concentrations, throughput needs to be as high as possible.
                      In addition, to ensure simplicity, a minimum of sample
                      preparation is important. Therefore, sorting schemes that
                      function for whole blood are highly desirable. Deterministic
                      lateral displacement (DLD) devices have proven to be very
                      precise and versatile in terms of a wide range of sorting
                      parameters. To better understand how DLD devices perform for
                      blood as the hematocrit increases, we carry out measurements
                      and simulations for spherical particles in the micrometer
                      range which move through DLD arrays for different flow
                      velocities and hematocrits ranging from pure buffer to
                      concentrated erythrocyte suspensions mimicking whole blood.
                      We find that the separation function of the DLD array is
                      sustained even though the blood cells introduce a shift in
                      the trajectories and a significant dispersion for particles
                      whose diameters are close to the critical size in the
                      device. Simulations qualitatively replicate our experimental
                      observations and help us identify fundamental mechanisms for
                      the effect of hematocrit on the performance of the DLD
                      device},
      cin          = {ICS-2 / JARA-HPC},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / $I:(DE-82)080012_20140620$},
      pnm          = {553 - Physical Basis of Diseases (POF3-553) / Blood flow in
                      microvascular networks $(jics21_20181101)$},
      pid          = {G:(DE-HGF)POF3-553 / $G:(DE-Juel1)jics21_20181101$},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000477919700002},
      doi          = {10.1103/PhysRevApplied.12.014051},
      url          = {https://juser.fz-juelich.de/record/864170},
}