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| 100 | 1 | _ | |a Daun, Silvia |0 P:(DE-Juel1)162297 |b 0 |u fzj |
| 245 | _ | _ | |a Unravelling intra- and intersegmental neuronal connectivity between central pattern generating networks in a multi-legged locomotor system |
| 260 | _ | _ | |a San Francisco, California, US |c 2019 |b PLOS |
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| 520 | _ | _ | |a Animal walking results from a complex interplay of central pattern generating networks (CPGs), local sensory signals expressing position, velocity and forces generated in the legs, and coordinating signals between neighboring legs. In particular, the CPGs control the activity of motoneuron (MN) pools which drive the muscles of the individual legs and are thereby responsible for the generation of rhythmic leg movements. The rhythmic activity of the CPGs as well as their connectivity can be modified by the aforementioned sensory signals. However, the precise nature of the interaction between the CPGs and these sensory signals has remained generally largely unknown. Experimental methods aiming at finding out details of these interactions often apply cholinergic agonists such as pilocarpine in order to induce rhythmic activity in the CPGs. Using this general approach, we removed the influence of sensory signals and investigated the putative connections between CPGs controlling the upward/downward movement in the different legs of the stick insect. The experimental data, i.e. the measured MN activities, underwent connectivity analysis using Dynamic Causal Modelling (DCM). This method can uncover the underlying coupling structure and strength between pairs of segmental CPGs. For the analysis we set up different coupling schemes (models) for DCM and compared them using Bayesian Model Selection (BMS). Models with contralateral connections in each segment and ipsilateral connections on both sides, as well as the coupling from the meta- to the ipsilateral prothoracic ganglion were preferred by BMS to all other types of models tested. Moreover, the intrasegmental coupling strength in the mesothoracic ganglion was the strongest and most stable in all three ganglia. |
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| 700 | 1 | _ | |a Mantziaris, Charalampos |0 P:(DE-HGF)0 |b 1 |
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| 700 | 1 | _ | |a Büschges, Ansgar |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Rosjat, Nils |0 P:(DE-Juel1)164124 |b 4 |e Corresponding author |u fzj |
| 773 | _ | _ | |a 10.1371/journal.pone.0220767 |g Vol. 14, no. 8, p. e0220767 - |0 PERI:(DE-600)2267670-3 |n 8 |p e0220767 - |t PLOS ONE |v 14 |y 2019 |x 1932-6203 |
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