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@ARTICLE{Simsek:864421,
      author       = {Simsek, Ahmet Nihat and Bräutigam, Andrea and Koch,
                      Matthias D. and Shaevitz, Joshua W. and Huang, Yunfei and
                      Gompper, Gerhard and Sabass, Benedikt},
      title        = {{S}ubstrate-rigidity dependent migration of an idealized
                      twitching bacterium},
      journal      = {Soft matter},
      volume       = {15},
      number       = {30},
      issn         = {1744-6848},
      address      = {London},
      publisher    = {Royal Soc. of Chemistry},
      reportid     = {FZJ-2019-04205},
      pages        = {6224 - 6236},
      year         = {2019},
      abstract     = {Mechanical properties of the extracellular matrix are
                      important determinants of cellular migration in diverse
                      processes, such as immune response, wound healing, and
                      cancer metastasis. Moreover, recent studies indicate that
                      even bacterial surface colonization can depend on the
                      mechanics of the substrate. Here, we focus on physical
                      mechanisms that can give rise to substrate-rigidity
                      dependent migration. We study a “twitcher”, a cell
                      driven by extension–retraction cycles, to idealize
                      bacteria and perhaps eukaryotic cells that employ a
                      slip-stick mode of motion. The twitcher is asymmetric and
                      always pulls itself forward at its front. Analytical
                      calculations show that the migration speed of a twitcher
                      depends non-linearly on substrate rigidity. For soft
                      substrates, deformations do not lead to build-up of
                      significant force and the migration speed is therefore
                      determined by stochastic adhesion unbinding. For rigid
                      substrates, forced adhesion rupture determines the migration
                      speed. Depending on the force-sensitivity of front and rear
                      adhesions, forced bond rupture implies an increase or a
                      decrease of the migration speed. A requirement for the
                      occurrence of rigidity-dependent stick-slip migration is a
                      “sticky” substrate, with binding rates being an order of
                      magnitude larger than unbinding rates in absence of force.
                      Computer simulations show that small stall forces of the
                      driving machinery lead to a reduced movement on high
                      rigidities, regardless of force-sensitivities of bonds. The
                      simulations also confirm the occurrence of
                      rigidity-dependent migration speed in a generic model for
                      slip-stick migration of cells on a sticky substrate.},
      cin          = {ICS-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31334524},
      UT           = {WOS:000477986500017},
      doi          = {10.1039/C9SM00541B},
      url          = {https://juser.fz-juelich.de/record/864421},
}