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@ARTICLE{Chien:864447,
      author       = {Chien, Wei and Zhang, Zunmin and Gompper, Gerhard and
                      Fedosov, Dmitry A.},
      title        = {{D}eformation and dynamics of erythrocytes govern their
                      traversal through microfluidic devices with a deterministic
                      lateral displacement architecture},
      journal      = {Biomicrofluidics},
      volume       = {13},
      number       = {4},
      issn         = {1932-1058},
      address      = {Melville, NY},
      publisher    = {AIP},
      reportid     = {FZJ-2019-04231},
      pages        = {044106},
      year         = {2019},
      abstract     = {Deterministic lateral displacement (DLD) microfluidic
                      devices promise versatile and precise processing of
                      biological samples. However, this prospect has been realized
                      so far only for rigid spherical particles and remains
                      limited for biological cells due to the complexity of cell
                      dynamics and deformation in microfluidic flow. We employ
                      mesoscopic hydrodynamics simulations of red blood cells
                      (RBCs) in DLD devices with circular posts to better
                      understand the interplay between cell behavior in complex
                      microfluidic flow and sorting capabilities of such devices.
                      We construct a mode diagram of RBC behavior (e.g.,
                      displacement, zig-zagging, and intermediate modes) and
                      identify several regimes of RBC dynamics (e.g., tumbling,
                      tank-treading, and trilobe motion). Furthermore, we link the
                      complex interaction dynamics of RBCs with the post to their
                      effective cell size and discuss relevant physical mechanisms
                      governing the dynamic cell states. In conclusion, sorting of
                      RBCs in DLD devices based on their shear elasticity is, in
                      general, possible but requires fine-tuning of flow
                      conditions to targeted mechanical properties of the RBCs},
      cin          = {ICS-2 / JARA-HPC},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / $I:(DE-82)080012_20140620$},
      pnm          = {552 - Engineering Cell Function (POF3-552) / Blood flow in
                      microvascular networks $(jics21_20181101)$},
      pid          = {G:(DE-HGF)POF3-552 / $G:(DE-Juel1)jics21_20181101$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31372194},
      UT           = {WOS:000483884200014},
      doi          = {10.1063/1.5112033},
      url          = {https://juser.fz-juelich.de/record/864447},
}