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@ARTICLE{Reuter:864579,
      author       = {Reuter, Jan André and Matuschke, Felix and Menzel, Miriam
                      and Schubert, Nicole and Ginsburger, Kévin and Poupon,
                      Cyril and Amunts, Katrin and Axer, Markus},
      title        = {{FAC}onstructor: an interactive tool for geometric modeling
                      of nerve fiber architectures in the brain},
      journal      = {International journal of computer assisted radiology and
                      surgery},
      volume       = {14},
      number       = {11},
      issn         = {1861-6429},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer},
      reportid     = {FZJ-2019-04297},
      pages        = {1881-1889},
      year         = {2019},
      abstract     = {PURPOSE: The technique 3D polarized light imaging (3D-PLI)
                      allows to reconstruct nerve fiber orientations of postmortem
                      brains with ultra-high resolution. To better understand the
                      physical principles behind 3D-PLI and improve the accuracy
                      and reliability of the reconstructed fiber orientations,
                      numerical simulations are employed which use synthetic nerve
                      fiber models as input. As the generation of fiber models can
                      be challenging and very time-consuming, we have developed
                      the open source FAConstructor tool which enables a fast and
                      efficient generation of synthetic fiber models for 3D-PLI
                      simulations. METHODS: The program was developed as an
                      interactive tool, allowing the user to define fiber pathways
                      with interpolation methods or parametric functions and
                      providing visual feedback.RESULTS: Performance tests showed
                      that most processes scale almost linearly with the amount of
                      fiber points in FAConstructor. Fiber models consisting of <
                      1.6 million data points retain a frame rate of more than 30
                      frames per second, which guarantees a stable and fluent
                      workflow. The applicability of FAConstructor was
                      demonstrated on a well-defined fiber model (Fiber Cup
                      phantom) for two different simulation approaches,
                      reproducing effects known from 3D-PLI
                      measurements.CONCLUSION: We have implemented a user-friendly
                      and efficient tool that enables an interactive and fast
                      generation of synthetic nerve fiber configurations for
                      3D-PLI simulations. Already existing fiber models can easily
                      be modified, allowing to simulate many different fiber
                      models in a reasonable amount of time.},
      cin          = {INM-1 / JARA-HPC},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / $I:(DE-82)080012_20140620$},
      pnm          = {574 - Theory, modelling and simulation (POF3-574) / 571 -
                      Connectivity and Activity (POF3-571) / HBP SGA2 - Human
                      Brain Project Specific Grant Agreement 2 (785907) /
                      Simulations for a better Understanding of the Impact of
                      Different Brain Tissue Components on 3D Polarized Light
                      Imaging $(jjsc43_20181101)$ / 3D Reconstruction of Nerve
                      Fibers in the Human, the Monkey, the Rodent, and the Pigeon
                      Brain $(jinm11_20181101)$},
      pid          = {G:(DE-HGF)POF3-574 / G:(DE-HGF)POF3-571 /
                      G:(EU-Grant)785907 / $G:(DE-Juel1)jjsc43_20181101$ /
                      $G:(DE-Juel1)jinm11_20181101$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31401715},
      UT           = {WOS:000496030000007},
      doi          = {10.1007/s11548-019-02053-6},
      url          = {https://juser.fz-juelich.de/record/864579},
}