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@ARTICLE{Richter:864642,
      author       = {Richter, Nils and Nellessen, Nils and Dronse, Julian and
                      Dillen, Kim and Jacobs, Heidi and Langen, Karl-Josef and
                      Kracht, Lutz and Dietlein, Markus and Neumaier, Bernd and
                      Fink, Gereon R. and Kukolja, Juraj and Onur, Oezguer A.},
      title        = {{S}patial distributions of cholinergic impairment and
                      neuronal hypometabolism differ in {MCI} due to {AD}},
      journal      = {NeuroImage: Clinical},
      volume       = {24},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2019-04344},
      pages        = {101978 -},
      year         = {2019},
      abstract     = {Elucidating the relationship between neuronal metabolism
                      and the integrity of the cholinergic system is prerequisite
                      for a profound understanding of cholinergic dysfunction in
                      Alzheimer's disease.The cholinergic system can be
                      investigated specifically using positron emission tomography
                      (PET) with [11C]N-methyl-4-piperidyl-acetate (MP4A), while
                      neuronal metabolism is often assessed with
                      2-deoxy-2-[18F]fluoro-d-glucose-(FDG) PET. We hypothesised a
                      close correlation between MP4A-perfusion and FDG-uptake,
                      permitting inferences about metabolism from MP4A-perfusion,
                      and investigated the patterns of neuronal hypometabolism and
                      cholinergic impairment in non-demented AD patients.MP4A-PET
                      was performed in 18 cognitively normal adults and 19
                      patients with mild cognitive impairment (MCI) and positive
                      AD biomarkers. In nine patients with additional FDG-PET, the
                      sum images of every combination of consecutive early
                      MP4A-frames were correlated with FDG-scans to determine the
                      optimal time window for assessing MP4A-perfusion.
                      Acetylcholinesterase (AChE) activity was estimated using a
                      3-compartmental model. Group comparisons of MP4A-perfusion
                      and AChE-activity were performed using the entire sample.The
                      highest correlation between MP4A-perfusion and FDG-uptake
                      across the cerebral cortex was observed 60–450 s after
                      injection (r = 0.867). The patterns of hypometabolism
                      (FDG-PET) and hypoperfusion (MP4A-PET) in MCI covered areas
                      known to be hypometabolic early in AD, while AChE activity
                      was mainly reduced in the lateral temporal cortex and the
                      occipital lobe, sparing posterior midline structures.Data
                      indicate that patterns of cholinergic impairment and
                      neuronal hypometabolism differ significantly at the stage of
                      MCI in AD, implying distinct underlying pathologies, and
                      suggesting potential predictors of the response to
                      cholinergic pharmacotherapy.},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31422337},
      UT           = {WOS:000504663800122},
      doi          = {10.1016/j.nicl.2019.101978},
      url          = {https://juser.fz-juelich.de/record/864642},
}