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000864681 1001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b0$$eCorresponding author
000864681 245__ $$aImaging challenges of immunotherapy and targeted therapy in patients with brain metastases: Response, Progression, and Pseudoprogression
000864681 260__ $$aOxford$$bOxford Univ. Press$$c2020
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000864681 520__ $$aThe advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy (TT) has dramatically improved the prognosis of various cancer types. However, following ICI therapy or TT—either alone (especially ICI) or in combination with radiotherapy—imaging findings on anatomical contrast-enhanced MRI can be unpredictable and highly variable, and are often difficult to interpret regarding treatment response and outcome. This review aims at summarizing the imaging challenges related to TT and ICI monotherapy as well as combined with radiotherapy in patients with brain metastases, and to give an overview on advanced imaging techniques which potentially overcome some of these imaging challenges. Currently, major evidence suggests that imaging parameters especially derived from amino acid PET, perfusion-/diffusion-weighted MRI, or MR spectroscopy may provide valuable additional information for the differentiation of treatment-induced changes from brain metastases recurrence and the evaluation of treatment response.
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000864681 7001_ $$0P:(DE-Juel1)173675$$aKocher, Martin$$b1
000864681 7001_ $$0P:(DE-HGF)0$$aCeccon, Garry$$b2
000864681 7001_ $$0P:(DE-HGF)0$$aWerner, Jan-Michael$$b3
000864681 7001_ $$0P:(DE-HGF)0$$aBrunn, Anna$$b4
000864681 7001_ $$0P:(DE-HGF)0$$aDeckert, Martina$$b5
000864681 7001_ $$0P:(DE-HGF)0$$aPope, Whitney B$$b6
000864681 7001_ $$0P:(DE-HGF)0$$aSoffietti, Riccardo$$b7
000864681 7001_ $$0P:(DE-HGF)0$$aLe Rhun, Emilie$$b8
000864681 7001_ $$0P:(DE-HGF)0$$aWeller, Michael$$b9
000864681 7001_ $$0P:(DE-HGF)0$$aTonn, Jörg C$$b10
000864681 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R$$b11
000864681 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b12
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