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@ARTICLE{Kaldybekov:864694,
      author       = {Kaldybekov, Daulet B. and Filippov, Sergey K. and
                      Radulescu, Aurel and Khutoryanskiy, Vitaliy V.},
      title        = {{M}aleimide-functionalised {PLGA}-{PEG} nanoparticles as
                      mucoadhesive carriers for intravesical drug delivery},
      journal      = {European journal of pharmaceutics and biopharmaceutics},
      volume       = {143},
      issn         = {0939-6411},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2019-04388},
      pages        = {24 - 34},
      year         = {2019},
      abstract     = {Low permeability of the urinary bladder epithelium, poor
                      retention of the chemotherapeutic agents due to dilution and
                      periodic urine voiding as well as intermittent
                      catheterisations are the major limitations of intravesical
                      drug delivery used in the treatment of bladder cancer. In
                      this work, maleimide-functionalised
                      poly(lactide-co-glycolide)-block-poly(ethylene glycol)
                      (PLGA-PEG-Mal) nanoparticles were developed. Their
                      physicochemical characteristics, including morphology,
                      architecture and molecular parameters have been investigated
                      by means of dynamic light scattering, transmission electron
                      microscopy and small-angle neutron scattering techniques. It
                      was established that the size of nanoparticles was dependent
                      on the solvent used in their preparation and molecular
                      weight of PEG, for example, 105 ± 1 nm and
                      68 ± 1 nm particles were formed from PLGA20K-PEG5K in
                      dimethyl sulfoxide and acetone, respectively. PLGA-PEG-Mal
                      nanoparticles were explored as mucoadhesive formulations for
                      drug delivery to the urinary bladder. The retention of
                      fluorescein-loaded nanoparticles on freshly excised lamb
                      bladder mucosa in vitro was evaluated and assessed using a
                      flow-through fluorescence technique and Wash Out50 (WO50)
                      quantitative method. PLGA-PEG-Mal nanoparticles (NPs)
                      exhibited greater retention on urinary bladder mucosa
                      (WO50 = 15 mL) compared to maleimide-free NPs
                      (WO50 = 5 mL). The assessment of the biocompatibility
                      of PEG-Mal using the slug mucosal irritation test revealed
                      that these materials are non-irritant to mucosal surfaces.},
      cin          = {JCNS-FRM-II / JCNS-1 / MLZ},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31419584},
      UT           = {WOS:000488421000004},
      doi          = {10.1016/j.ejpb.2019.08.007},
      url          = {https://juser.fz-juelich.de/record/864694},
}