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@ARTICLE{Antoine:864755,
      author       = {Antoine, Nicolas and Bahri, Mohamed A. and Bastin,
                      Christine and Collette, Fabienne and Phillips, Christophe
                      and Balteau, Evelyne and Genon, Sarah and Salmon, Eric},
      title        = {{A}nosognosia and default mode subnetwork dysfunction in
                      {A}lzheimer's disease},
      journal      = {Human brain mapping},
      volume       = {40},
      number       = {18},
      issn         = {1097-0193},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2019-04422},
      pages        = {5330-5340},
      year         = {2019},
      note         = {Funding informationFondation Roi Baudouin - Belgique,
                      Grant/Award Number: Fonds Maria Elisa et Guillaumede Beys;
                      Fonds De La Recherche Scientifique -FNRS; GE Healthcare,
                      Grant/Award Number:Investigator Sponsored Study
                      (ISS290);InterUniversity Attraction Pole, BELSPO,Grant/Award
                      Number: IUAP 7/11; Universityof Liege, Grant/Award Number:
                      ConcertedAction 12/17-01},
      abstract     = {Research on the neural correlates of anosognosia in
                      Alzheimer's disease varied accordingto methods and
                      objectives: they compared different measures, used diverse
                      neuroimag-ing modalities, explored connectivity between
                      brain networks, addressed the role of spe-cific brain
                      regions or tried to give support to theoretical models of
                      unawareness. Weused resting-state fMRI connectivity with two
                      different seed regions and two measuresof anosognosia in
                      different patient samples toinvestigate consistent
                      modifications ofdefault mode subnetworks and we aligned the
                      results with the Cognitive AwarenessModel. In a first study,
                      patients and their relatives were presented with the
                      MemoryAwareness Rating Scale. Anosognosia was measured as a
                      patient-relative discrepancyscore and connectivity was
                      investigated with a parahippocampal seed. In a second
                      study,anosognosiawasmeasuredinpatientswithbrainamyloid(takenasadiseasebiomarker)by
                      comparing self-reported rating with memory performance, and
                      connectivity wasexamined with a hippocampal seed. In both
                      studies, anosognosia was consistently relatedto
                      disconnection within the medial temporal subsystem of the
                      default mode network,subserving episodic memory processes.
                      Importantly, scores were also related to discon-nection
                      between the medial temporal and
                      boththecoresubsystem(participating to self-reflection) and
                      the dorsomedial subsystem of the default mode network (the
                      middle tem-poral gyrus that might subserve a personal
                      database in the second study). We suggestthat disparity in
                      connectivity within and between subsystems of the default
                      mode net-work may reflect impaired functioning of pathways
                      in cognitive models of awareness.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31444942},
      UT           = {WOS:000483263300001},
      doi          = {10.1002/hbm.24775},
      url          = {https://juser.fz-juelich.de/record/864755},
}