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@INPROCEEDINGS{Lohmann:864916,
      author       = {Lohmann, Philipp and Stavrinou, P. and Lipke, K. and Bauer,
                      E. K. and Ceccon, G. and Werner, J. M. and Neumaier, B. and
                      Fink, G. R. and Shah, N. J. and Langen, K. J. and Galldiks,
                      N.},
      title        = {{FET} {PET} reveals considerable spatial differences in
                      tumour burden compared to conventional {MRI} in newly
                      diagnosed glioblastoma.},
      reportid     = {FZJ-2019-04519},
      year         = {2019},
      abstract     = {V54FET PET reveals considerable spatial differences in
                      tumour burden compared to conventional MRI in newly
                      diagnosed glioblastomaP. Lohmann1, P. Stavrinou2, K. Lipke1,
                      E. K. Bauer3, G. Ceccon3, J. Werner3, B. Neumaier1, G. R.
                      Fink3, N. J. Shah1, K. Langen1, N.
                      Galldiks31Forschungszentrum Jülich, Institute of
                      Neuroscience and Medicine, Jülich; 2University of Cologne,
                      Dept. of Neurosurgery, Cologne; 3University of Cologne,
                      Dept. of Neurology, CologneZiel/Aim:Contrast enhancement
                      (CE) in MRI is usually the target for resection or
                      radiotherapy target volume definition in glioblastomas.
                      However, the solid tumour mass may extend beyond areas of
                      CE. Amino acid PET can detect such tumour parts that show no
                      CE. We systematically investigated tumour volumes delineated
                      by amino acid PET and MRI in newly diagnosed, untreated
                      glioblastoma patients.Methodik/Methods:Preoperatively, 50
                      patients with neuropathologically confirmed glioblastoma
                      underwent O-(2-[F-18]-fluoroethyl)-L-tyrosine (FET) PET,
                      fluid-attenuated inversion recovery (FLAIR) and
                      contrast-enhanced MRI. Areas of CE were manually segmented.
                      FET PET tumour volumes were segmented using a
                      tumour-to-brain ratio of 1.6. The percentage of overlapping
                      volumes (OV), Dice and Jaccard spatial similarity
                      coefficients (DSC; JSC) were calculated. FLAIR images were
                      evaluated visually.Ergebnisse/Results:In $86\%$ of patients
                      (n = 43), the FET tumour volume was significantly larger
                      than the volume of CE (21.5 ± 14.3 mL vs. 9.4 ± 11.3 mL; P
                      < 0.001). Forty patients $(80\%)$ showed both an increased
                      uptake of FET and CE. In these 40 patients, the spatial
                      similarity between FET and CE was low (mean DSC, 0.39 ±
                      0.21; mean JSC, 0.26 ± 0.16). Ten patients $(20\%)$ showed
                      no CE, and one of these patients showed no FET uptake. In
                      $10\%$ of patients (n = 5), increased FET uptake was present
                      outside of areas of FLAIR
                      hyperintensity.Schlussfolgerungen/Conclusions:Our data show
                      that the metabolically active tumour volume delineated by
                      FET PET is significantly larger than tumour volume
                      delineated by CE. Furthermore, the data strongly suggest
                      that the information derived from both imaging modalities
                      should be integrated into the management of newly diagnosed
                      glioblastoma patients.},
      month         = {Apr},
      date          = {2019-04-03},
      organization  = {Germany, Bremen (Bremen), 3 Apr 2019 -
                       6 Apr 2019},
      cin          = {INM-3 / INM-4 / INM-5},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)1},
      url          = {https://juser.fz-juelich.de/record/864916},
}