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@ARTICLE{Orlovskaya:864918,
      author       = {Orlovskaya, Victoriya V. and Modemann, Daniel and
                      Kutnetsova, Olga F. and Fedorova, Olga S. and Urusova,
                      Elizaveta and Kolks, Niklas and Neumaier, Bernd and
                      Krasikova, Raisa N. and Zlatopolskiy, Boris},
      title        = {{A}lcohol-{S}upported {C}u-{M}ediated 18{F}-{F}luorination
                      of {I}odonium {S}alts under “{M}inimalist” {C}onditions},
      journal      = {Molecules},
      volume       = {24},
      number       = {17},
      issn         = {1420-3049},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2019-04521},
      pages        = {3197},
      year         = {2019},
      abstract     = {In the era of personalized precision medicine, positron
                      emission tomography (PET) and related hybrid methods like
                      PET/CT and PET/MRI gain recognition as indispensable tools
                      of clinical diagnostics. A broader implementation of these
                      imaging modalities in clinical routine is closely dependent
                      on the increased availability of established and emerging
                      PET-tracers, which in turn could be accessible by the
                      development of simple, reliable, and efficient radiolabeling
                      procedures. A further requirement is a cGMP production of
                      imaging probes in automated synthesis modules. Herein, a
                      novel protocol for the efficient preparation of 18F-labeled
                      aromatics via Cu-mediated radiofluorination of
                      (aryl)(mesityl)iodonium salts without the need of
                      evaporation steps is described. Labeled aromatics were
                      prepared in high radiochemical yields simply by heating of
                      iodonium [18F]fluorides with the Cu-mediator in methanolic
                      DMF. The iodonium [18F]fluorides were prepared by direct
                      elution of 18F− from an anion exchange resin with
                      solutions of the corresponding precursors in MeOH/DMF. The
                      practicality of the novel method was confirmed by the
                      racemization-free production of radiolabeled
                      fluorophenylalanines, including hitherto unknown
                      3-[18F]FPhe, in $22–69\%$ isolated radiochemical yields as
                      well as its direct implementation into a remote-controlled
                      synthesis unit.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31484375},
      UT           = {WOS:000488613700177},
      doi          = {10.3390/molecules24173197},
      url          = {https://juser.fz-juelich.de/record/864918},
}