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| Hauptseite > Publikationsdatenbank > Alcohol-Supported Cu-Mediated 18F-Fluorination of Iodonium Salts under “Minimalist” Conditions > print |
| Hauptseite > Publikationsdatenbank > Alcohol-Supported Cu-Mediated 18F-Fluorination of Iodonium Salts under “Minimalist” Conditions > print |
| 001 | 864918 | ||
| 005 | 20220930130218.0 | ||
| 024 | 7 | _ | |a 10.3390/molecules24173197 |2 doi |
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| 037 | _ | _ | |a FZJ-2019-04521 |
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| 100 | 1 | _ | |a Orlovskaya, Victoriya V. |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Alcohol-Supported Cu-Mediated 18F-Fluorination of Iodonium Salts under “Minimalist” Conditions |
| 260 | _ | _ | |a Basel |c 2019 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a In the era of personalized precision medicine, positron emission tomography (PET) and related hybrid methods like PET/CT and PET/MRI gain recognition as indispensable tools of clinical diagnostics. A broader implementation of these imaging modalities in clinical routine is closely dependent on the increased availability of established and emerging PET-tracers, which in turn could be accessible by the development of simple, reliable, and efficient radiolabeling procedures. A further requirement is a cGMP production of imaging probes in automated synthesis modules. Herein, a novel protocol for the efficient preparation of 18F-labeled aromatics via Cu-mediated radiofluorination of (aryl)(mesityl)iodonium salts without the need of evaporation steps is described. Labeled aromatics were prepared in high radiochemical yields simply by heating of iodonium [18F]fluorides with the Cu-mediator in methanolic DMF. The iodonium [18F]fluorides were prepared by direct elution of 18F− from an anion exchange resin with solutions of the corresponding precursors in MeOH/DMF. The practicality of the novel method was confirmed by the racemization-free production of radiolabeled fluorophenylalanines, including hitherto unknown 3-[18F]FPhe, in 22–69% isolated radiochemical yields as well as its direct implementation into a remote-controlled synthesis unit. |
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| 700 | 1 | _ | |a Kutnetsova, Olga F. |0 P:(DE-HGF)0 |b 2 |
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| 700 | 1 | _ | |a Kolks, Niklas |0 P:(DE-Juel1)178654 |b 5 |
| 700 | 1 | _ | |a Neumaier, Bernd |0 P:(DE-Juel1)166419 |b 6 |e Corresponding author |
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| 700 | 1 | _ | |a Zlatopolskiy, Boris |0 P:(DE-Juel1)176188 |b 8 |
| 773 | _ | _ | |a 10.3390/molecules24173197 |0 PERI:(DE-600)2008644-1 |n 17 |p 3197 |t Molecules |v 24 |y 2019 |x 1420-3049 |
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