Hauptseite > Publikationsdatenbank > Comparison of [18F]-Fluoroethyltyrosine PET and the IDH status with Sodium MRI in Cerebral Gliomas > print

001     864921
005     20210130002754.0
037 _ _ |a FZJ-2019-04524
100 1 _ |a Shymanskaya, Aliaksandra
|0 P:(DE-Juel1)167471
|b 0
|u fzj
111 2 _ |a Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin 2019
|c Bremen
|d 2019-04-03 - 2019-04-06
|w Germany
245 _ _ |a Comparison of [18F]-Fluoroethyltyrosine PET and the IDH status with Sodium MRI in Cerebral Gliomas
260 _ _ |c 2019
336 7 _ |a Abstract
|b abstract
|m abstract
|0 PUB:(DE-HGF)1
|s 1567774921_16307
|2 PUB:(DE-HGF)
336 7 _ |a Conference Paper
|0 33
|2 EndNote
336 7 _ |a INPROCEEDINGS
|2 BibTeX
336 7 _ |a conferenceObject
|2 DRIVER
336 7 _ |a Output Types/Conference Abstract
|2 DataCite
336 7 _ |a OTHER
|2 ORCID
520 _ _ |a V56Comparison of [18F]-Fluoroethyltyrosine PET and the IDH status with Sodium MRI in Cerebral GliomasA. Shymanskaya1, W. A. Worthoff1, G. Stoffels1, J. Lindemeyer1, B. Neumaier2, P. Lohmann1, N. Galldiks3, K. J. Langen1, N. J. Shah11Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine - 4, Jülich, Germany; 2Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine - 5, Jülich, Germany; 3Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine - 3, Jülich, GermanyZiel/Aim:O-(2-[18F]fluoroethyl)-L-tyrosine([18F]-FET) PET is used for the supportive diagnostics of cerebral gliomas. In this study, the relationship between the [18F]-FET-PET parameters, distribution of restricted (mainly intracellular) and unrestricted (mainly extracellular) sodium, and the mutational status of the enzyme isocitrate dehydrogenase (IDH) were investigated in patients with cerebral gliomas.Methodik/Methods:Ten patients with untreated gliomas and one patient with a recurrent glioblastoma were investigated by dynamic [18F]-FET-PET and sodium MRI using an enhanced SISTINA sequence to estimate sodium parameters in tumours. The enhanced SISTINA sequence uses single-quantum and triple-quantum-filtered imaging and allows simultaneous acquisition of signal originating from restricted and unrestricted sodium (1). IDH mutational status was determined after biopsy or resection. The untreated patients were analysed independently in two groups (5 patients each) dependent on their IDH mutational status.Ergebnisse/Results:Tumour-to-brain ratio (TBR) of weighted mainly intracellular sodium (NaR) was significantly lower in IDH mutated (p=0.01) than in IDH wildtype gliomas. Total sodium concentration in mmol/L (p=0.05), TBR of the total sodium concentration (NaT) (p=0.02), TBR of weighted unrestricted mainly extracellular sodium (NaNR) (p=0.003), and the ratio of NaT/NaR (p<0.001) were significantly higher in IDH mutated than in IDH wildtype gliomas. [18F]-FET parameters estimated from tracer dynamics curves (TBR, time-to-peak) correlated neither to the IDH status nor to the sodium distribution. The patient with a recurrent GBM exhibited an additional radiation injury with strong abnormalities in sodium MRI.Schlussfolgerungen/Conclusions:Acquired results show that sodium MRI shows stronger relation to the IDH mutational status than [18F]-FET-PET parameters in cerebral gliomas in this patient cohort. Further evaluation of the combination of the three diagnostic modalities in gliomas seems promising and requires higher patient number.Literatur/References:[1] Worthoff WA, Shymanskaya A, Shah NJ. Relaxometry and quantification in simultaneously acquired single and triple quantum filtered sodium MRI. Magn Reson Med. 2018;00:1-13. doi:10.1002/mrm.27387.
536 _ _ |a 572 - (Dys-)function and Plasticity (POF3-572)
|0 G:(DE-HGF)POF3-572
|c POF3-572
|f POF III
|x 0
700 1 _ |a Worthoff, W. A.
|0 P:(DE-Juel1)156200
|b 1
|u fzj
700 1 _ |a Stoffels, G.
|0 P:(DE-Juel1)131627
|b 2
|u fzj
700 1 _ |a Lindemeyer, J.
|0 P:(DE-Juel1)131657
|b 3
|u fzj
700 1 _ |a Neumaier, B.
|0 P:(DE-Juel1)166419
|b 4
|u fzj
700 1 _ |a Lohmann, P.
|0 P:(DE-Juel1)145110
|b 5
|u fzj
700 1 _ |a Galldiks, N.
|0 P:(DE-Juel1)143792
|b 6
|u fzj
700 1 _ |a Langen, K. J.
|0 P:(DE-Juel1)131777
|b 7
|u fzj
700 1 _ |a Shah, N. J.
|0 P:(DE-Juel1)131794
|b 8
|u fzj
856 4 _ |u https://www.nuklearmedizin.de/jahrestagungen/abstr_online2019/abstract_detail.php?navId=227&aId=17
909 C O |o oai:juser.fz-juelich.de:864921
|p VDB
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 0
|6 P:(DE-Juel1)167471
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 1
|6 P:(DE-Juel1)156200
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 2
|6 P:(DE-Juel1)131627
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 3
|6 P:(DE-Juel1)131657
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 4
|6 P:(DE-Juel1)166419
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 5
|6 P:(DE-Juel1)145110
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 6
|6 P:(DE-Juel1)143792
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 7
|6 P:(DE-Juel1)131777
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 8
|6 P:(DE-Juel1)131794
913 1 _ |a DE-HGF
|b Key Technologies
|l Decoding the Human Brain
|1 G:(DE-HGF)POF3-570
|0 G:(DE-HGF)POF3-572
|2 G:(DE-HGF)POF3-500
|v (Dys-)function and Plasticity
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2019
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)INM-3-20090406
|k INM-3
|l Kognitive Neurowissenschaften
|x 0
920 1 _ |0 I:(DE-Juel1)INM-4-20090406
|k INM-4
|l Physik der Medizinischen Bildgebung
|x 1
920 1 _ |0 I:(DE-Juel1)INM-5-20090406
|k INM-5
|l Nuklearchemie
|x 2
920 1 _ |0 I:(DE-Juel1)INM-11-20170113
|k INM-11
|l Jara-Institut Quantum Information
|x 3
980 _ _ |a abstract
980 _ _ |a VDB
980 _ _ |a I:(DE-Juel1)INM-3-20090406
980 _ _ |a I:(DE-Juel1)INM-4-20090406
980 _ _ |a I:(DE-Juel1)INM-5-20090406
980 _ _ |a I:(DE-Juel1)INM-11-20170113
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21