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@ARTICLE{Liang:865136,
      author       = {Liang, Yuanying and Wu, Changtong and Figueroa-Miranda,
                      Gabriela and Offenhäusser, Andreas and Mayer, Dirk},
      title        = {{A}mplification of aptamer sensor signals by four orders of
                      magnitude via interdigitated organic electrochemical
                      transistors},
      journal      = {Biosensors and bioelectronics},
      volume       = {144},
      issn         = {0956-5663},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2019-04688},
      pages        = {111668 -},
      year         = {2019},
      abstract     = {Electrochemical aptamer receptor/transducer systems are key
                      elements of emerging E-AB sensors (aptasensor) used for the
                      detection of various kinds of targets. However, the
                      performance of these amperometric sensors is often limited
                      by the low density of receptors attached to the sensor
                      surface and high background signals. In the present work,
                      interdigitated organic electrochemical transistors (iOECT)
                      were used as a transducer to enhance the sensitivity and
                      dynamic detection range of aptasensors. Therefore, the
                      electrode of an amperometric sensor was utilized as gate
                      electrode to operate the iOECT. This device was used to
                      detect the low weight target molecule adenosine triphosphate
                      (ATP), a common biomarker, which plays an important role for
                      cardiovascular, neurodegenerative, and immune deficiency
                      diseases. The novel aptasensor can selectively detect ATP
                      with ultrahigh sensitivity down to the concentration of 10
                      pM, which is four orders of magnitude lower than the
                      detection limit of the same aptasensor using an amperometric
                      transducer principle (limit-of-detection of 106 nM) and
                      most other previously reported electrochemical sensors.
                      Furthermore, sensor regeneration was demonstrated, which
                      facilitates reusability of OECT aptasensors. The small
                      device size in combination with high transconductances paves
                      the way for the development of highly sensitive integrated
                      micro-biosensors for point-of-care applications.},
      cin          = {ICS-8},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31522101},
      UT           = {WOS:000497249300025},
      doi          = {10.1016/j.bios.2019.111668},
      url          = {https://juser.fz-juelich.de/record/865136},
}