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| Hauptseite > Publikationsdatenbank > Fully Printed μ-Needle Electrode Array from Conductive Polymer Ink for Bioelectronic Applications > print |
| Hauptseite > Publikationsdatenbank > Fully Printed μ-Needle Electrode Array from Conductive Polymer Ink for Bioelectronic Applications > print |
| 001 | 865138 | ||
| 005 | 20240619091251.0 | ||
| 024 | 7 | _ | |a 10.1021/acsami.9b11774 |2 doi |
| 024 | 7 | _ | |a 1944-8244 |2 ISSN |
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| 024 | 7 | _ | |a pmid:31424902 |2 pmid |
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| 037 | _ | _ | |a FZJ-2019-04690 |
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| 100 | 1 | _ | |a Zips, Sabine |0 0000-0003-4289-2943 |b 0 |
| 245 | _ | _ | |a Fully Printed μ-Needle Electrode Array from Conductive Polymer Ink for Bioelectronic Applications |
| 260 | _ | _ | |a Washington, DC |c 2019 |b Soc. |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1568639897_13616 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Microelectrode arrays (MEAs) are widely used platforms in bioelectronics to study electrogenic cells. In recent years, the processing of conductive polymers for the fabrication of three-dimensional electrode arrays has gained increasing interest for the development of novel sensor designs. Here, additive manufacturing techniques are promising tools for the production of MEAs with three-dimensional electrodes. In this work, a facile additive manufacturing process for the fabrication of MEAs that feature needle-like electrode tips, so-called μ-needles, is presented. To this end, an aerosol-jet compatible PEDOT:PSS and multiwalled carbon nanotube composite ink with a conductivity of 323 ± 75 S m–1 is developed and used in a combined inkjet and aerosol-jet printing process to produce the μ-needle electrode features. The μ-needles are fabricated with a diameter of 10 ± 2 μm and a height of 33 ± 4 μm. They penetrate an inkjet-printed dielectric layer to a height of 12 ± 3 μm. After successful printing, the electrochemical properties of the devices are assessed via cyclic voltammetry and impedance spectroscopy. The μ-needles show a capacitance of 242 ± 70 nF at a scan rate of 5 mV s–1 and an impedance of 128 ± 22 kΩ at 1 kHz frequency. The stability of the μ-needle MEAs in aqueous electrolyte is demonstrated and the devices are used to record extracellular signals from cardiomyocyte-like HL-1 cells. This proof-of-principle experiment shows the μ-needle MEAs’ cell-culture compatibility and functional integrity to investigate electrophysiological signals from living cells. |
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| 700 | 1 | _ | |a Terkan, Korkut |0 0000-0002-9060-884X |b 3 |
| 700 | 1 | _ | |a Adly, Nouran Yehia |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Weiß, Lennart Jakob Konstantin |0 0000-0002-6943-737X |b 5 |
| 700 | 1 | _ | |a Mayer, Dirk |0 P:(DE-Juel1)128707 |b 6 |
| 700 | 1 | _ | |a Wolfrum, Bernhard |0 P:(DE-Juel1)128745 |b 7 |e Corresponding author |
| 773 | _ | _ | |a 10.1021/acsami.9b11774 |g Vol. 11, no. 36, p. 32778 - 32786 |0 PERI:(DE-600)2467494-1 |n 36 |p 32778 - 32786 |t ACS applied materials & interfaces |v 11 |y 2019 |x 1944-8252 |
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