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@ARTICLE{Maurer:865195,
      author       = {Maurer, Gabriele D and Brucker, Daniel P and Stoffels,
                      Gabriele and Filipski, Katharina and Filss, Christian P and
                      Mottaghy, Felix M. and Galldiks, Norbert and Steinbach,
                      Joachim P and Hattingen, Elke and Langen, Karl-Josef},
      title        = {18 {F}-{FET} {PET} imaging in differentiating glioma
                      progression from treatment-related changes – a
                      single-center experience},
      journal      = {Journal of nuclear medicine},
      volume       = {61},
      number       = {4},
      issn         = {2159-662X},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {FZJ-2019-04731},
      pages        = {505-511},
      year         = {2020},
      abstract     = {In glioma patients, differentiation between tumor
                      progression (TP) and treatment-related changes (TRCs)
                      remains challenging. Difficulties in classifying imaging
                      alterations may result in a delay or an unnecessary
                      discontinuation of treatment. PET using
                      O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) has been shown to
                      be a useful tool for detecting TP and TRCs. Methods: We
                      retrospectively evaluated 127 consecutive patients with
                      World Health Organization grade II–IV glioma who underwent
                      18F-FET PET imaging to distinguish between TP and TRCs.
                      18F-FET PET findings were verified by neuropathology (40
                      patients) or clinicoradiologic follow-up (87 patients).
                      Maximum tumor-to-brain ratios (TBRmax) of 18F-FET uptake and
                      the slope of the time–activity curves (20–50 min after
                      injection) were determined. The diagnostic accuracy of
                      18F-FET PET parameters was evaluated by
                      receiver-operating-characteristic analysis and χ2 testing.
                      The prognostic value of 18F-FET PET was estimated using the
                      Kaplan–Meier method. Results: TP was diagnosed in 94
                      patients $(74\%)$ and TRCs in 33 $(26\%).$ For
                      differentiating TP from TRCs,
                      receiver-operating-characteristic analysis yielded an
                      optimal 18F-FET TBRmax cutoff of 1.95 (sensitivity, $70\%;$
                      specificity, $71\%;$ accuracy, $70\%;$ area under the curve,
                      0.75 ± 0.05). The highest accuracy was achieved by a
                      combination of TBRmax and slope (sensitivity, $86\%;$
                      specificity, $67\%;$ accuracy, $81\%).$ However, accuracy
                      was poorer when tumors harbored isocitrate dehydrogenase
                      (IDH) mutations $(91\%$ in IDH-wild-type tumors, $67\%$ in
                      IDH-mutant tumors, P < 0.001). 18F-FET PET results
                      correlated with overall survival (P < 0.001). Conclusion: In
                      our neurooncology department, the diagnostic performance of
                      18F-FET PET was convincing but slightly inferior to that of
                      previous reports.},
      cin          = {INM-3 / INM-4 / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-11-20170113},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31519802},
      UT           = {WOS:000530831100030},
      doi          = {10.2967/jnumed.119.234757},
      url          = {https://juser.fz-juelich.de/record/865195},
}