TY  - JOUR
AU  - Scarpazza, Cristina
AU  - Lattanzi, Guido Maria
AU  - Antoniades, Mathilde
AU  - Di Fabio, Fabio
AU  - Sartori, Giuseppe
AU  - Eickhoff, Simon B.
AU  - McGuire, Philip
AU  - Tognin, Stefania
TI  - Systematic review and multi-modal meta-analysis of magnetic resonance imaging findings in 22q11.2 deletion syndrome: Is more evidence needed?
JO  - Neuroscience & biobehavioral reviews
VL  - 107
SN  - 0149-7634
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2019-04768
SP  - 143 - 153
PY  - 2019
AB  - 22q11.2 deletion syndrome (DS) is considered to be the most robust genetic model of psychosis. In the last decade, there has been increased interest in the brain abnormalities associated with these genetic changes. Most imaging findings in this population come from small samples. This increases the risk of reporting spurious effects that reflect the idiosyncrasies of each study. Thus, the current work is aimed at identifying whether there are spatially consistent structural and functional brain abnormalities in individuals with 22q11.2 DS through (i) a comprehensive label-based systematic review and (ii) a coordinate-based meta-analysis of magnetic resonance imaging studies. The systematic review identified the frontal middle gyri, posterior cingulum, right cuneus and bilateral precuneus as the most affected regions. The meta-analysis revealed consistent abnormalities in the bilateral inferior parietal lobe, right precuneus, right superior temporal gyrus and posterior cingulate cortex. This study provides an important starting point for future research as it sheds light on possible genetically determined psychosis susceptibility regions.
LB  - PUB:(DE-HGF)16
C6  - pmid:31493414
UR  - <Go to ISI:>//WOS:000501388000014
DO  - DOI:10.1016/j.neubiorev.2019.09.004
UR  - https://juser.fz-juelich.de/record/865237
ER  -