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@ARTICLE{Hillringhaus:865247,
      author       = {Hillringhaus, Sebastian and Dasanna, Anil K. and Gompper,
                      Gerhard and Fedosov, Dmitry A.},
      title        = {{I}mportance of {E}rythrocyte {D}eformability for the
                      {A}lignment of {M}alaria {P}arasite upon {I}nvasion},
      journal      = {Biophysical journal},
      volume       = {117},
      number       = {7},
      issn         = {0006-3495},
      address      = {Bethesda, Md.},
      publisher    = {Soc.},
      reportid     = {FZJ-2019-04771},
      pages        = {1202-1214},
      year         = {2019},
      abstract     = {Invasion of erythrocytes by merozoites is an essential step
                      for the survival and progression of malaria parasites. To
                      invade red blood cells (RBCs), apicomplexan parasites have
                      to adhere with their apex to the RBC membrane. This
                      necessary apex-membrane contact (or alignment) is not
                      immediately established because the orientation of a free
                      merozoite with respect to the RBC membrane is random when an
                      adhesion contact first occurs. Therefore, it has been
                      suggested that after the initial adhesion, merozoites
                      facilitate their proper alignment by inducing considerable
                      membrane deformations, frequently observed before the
                      invasion process. This proposition is based on a positive
                      correlation between RBC membrane deformation and successful
                      invasion; however, the role of RBC mechanics and its
                      deformation in the alignment process remains elusive. Using
                      a mechanically realistic model of a deformable RBC, we
                      investigate numerically the importance of RBC deformability
                      for merozoite alignment. Adhesion between the parasite and
                      RBC membrane is modeled by an attractive potential that
                      might be inhomogeneous, mimicking possible adhesion
                      gradients at the surface of a parasite. Our results show
                      that RBC membrane deformations are crucial for successful
                      merozoite alignment and require interaction strengths
                      comparable to adhesion forces measured experimentally.
                      Adhesion gradients along the parasite body further improve
                      its alignment. Finally, an increased membrane rigidity is
                      found to result in poor merozoite alignment, which can be a
                      possible reason for a reduction in the invasion
                      susceptibility of RBCs in several blood diseases associated
                      with membrane stiffening.},
      cin          = {ICS-2 / JARA-HPC},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / $I:(DE-82)080012_20140620$},
      pnm          = {552 - Engineering Cell Function (POF3-552) / Formation of
                      Polymer-Particle Aggregates in Blood Flow
                      $(jiff44_20180501)$},
      pid          = {G:(DE-HGF)POF3-552 / $G:(DE-Juel1)jiff44_20180501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31540708},
      UT           = {WOS:000488457600004},
      doi          = {10.1016/j.bpj.2019.08.027},
      url          = {https://juser.fz-juelich.de/record/865247},
}