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000865288 1001_ $$0P:(DE-Juel1)131964$$aGordeliy, Valentin$$b0$$eCorresponding author
000865288 245__ $$aUnique structure and function of viral rhodopsins
000865288 260__ $$a[London]$$bNature Publishing Group UK$$c2019
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000865288 520__ $$aRecently, two groups of rhodopsin genes were identified in large double-stranded DNA viruses. The structure and function of viral rhodopsins are unknown. We present functional characterization and high-resolution structure of an Organic Lake Phycodnavirus rhodopsin II (OLPVRII) of group 2. It forms a pentamer, with a symmetrical, bottle-like central channel with the narrow vestibule in the cytoplasmic part covered by a ring of 5 arginines, whereas 5 phenylalanines form a hydrophobic barrier in its exit. The proton donor E42 is placed in the helix B. The structure is unique among the known rhodopsins. Structural and functional data and molecular dynamics suggest that OLPVRII might be a light-gated pentameric ion channel analogous to pentameric ligand-gated ion channels, however, future patch clamp experiments should prove this directly. The data shed light on a fundamentally distinct branch of rhodopsins and may contribute to the understanding of virus-host interactions in ecologically important marine protists.
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000865288 536__ $$0G:(DE-Juel1)jara0191_20181101$$aScreening the impurity effects on transport properties in topological materials (jara0191_20181101)$$cjara0191_20181101$$fScreening the impurity effects on transport properties in topological materials$$x2
000865288 536__ $$0G:(DE-Juel1)jara0177_20171101$$aMolecular dynamics of the SLC26 family of ion channels and transporters (jara0177_20171101)$$cjara0177_20171101$$fMolecular dynamics of the SLC26 family of ion channels and transporters$$x3
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000865288 7001_ $$0P:(DE-Juel1)131953$$aBratanov, Dmitry$$b1
000865288 7001_ $$0P:(DE-Juel1)165629$$aKovalev, Kirill$$b2
000865288 7001_ $$0P:(DE-Juel1)156429$$aMachtens, Jan-Philipp$$b3
000865288 7001_ $$0P:(DE-HGF)0$$aAstashkin, Roman$$b4
000865288 7001_ $$0P:(DE-HGF)0$$aChizhov, Igor$$b5
000865288 7001_ $$0P:(DE-HGF)0$$aSoloviov, Dmytro$$b6
000865288 7001_ $$0P:(DE-Juel1)176195$$aVolkov, Dmytro$$b7$$ufzj
000865288 7001_ $$0P:(DE-HGF)0$$aPolovinkin, Vitaly$$b8
000865288 7001_ $$0P:(DE-Juel1)176570$$aZabelskii, Dmitrii$$b9$$ufzj
000865288 7001_ $$0P:(DE-HGF)0$$aMager, Thomas$$b10
000865288 7001_ $$0P:(DE-Juel1)165798$$aGushchin, Ivan$$b11
000865288 7001_ $$0P:(DE-HGF)0$$aRokitskaya, Tatyana$$b12
000865288 7001_ $$0P:(DE-HGF)0$$aAntonenko, Yuri$$b13
000865288 7001_ $$0P:(DE-Juel1)169221$$aAlekseev, Alexey$$b14
000865288 7001_ $$0P:(DE-Juel1)171538$$aShevchenko, Vitaly$$b15
000865288 7001_ $$0P:(DE-HGF)0$$aYutin, Natalya$$b16
000865288 7001_ $$0P:(DE-HGF)0$$aRosselli, Riccardo$$b17
000865288 7001_ $$0P:(DE-Juel1)131948$$aBaeken, Christian$$b18$$ufzj
000865288 7001_ $$0P:(DE-Juel1)179072$$aBorshchevskiy, Valentin$$b19$$ufzj
000865288 7001_ $$0P:(DE-HGF)0$$aBourenkov, Gleb$$b20
000865288 7001_ $$0P:(DE-HGF)0$$aPopov, Alexander$$b21
000865288 7001_ $$0P:(DE-Juel1)131949$$aBalandin, Taras$$b22$$ufzj
000865288 7001_ $$0P:(DE-Juel1)131957$$aBüldt, Georg$$b23
000865288 7001_ $$0P:(DE-HGF)0$$aManstein, Dietmar J.$$b24
000865288 7001_ $$0P:(DE-HGF)0$$aRodriguez-Valera, Francisco$$b25
000865288 7001_ $$0P:(DE-Juel1)136837$$aFahlke, Christoph$$b26$$ufzj
000865288 7001_ $$0P:(DE-HGF)0$$aBamberg, Ernst$$b27
000865288 7001_ $$0P:(DE-HGF)0$$aKoonin, Eugene$$b28
000865288 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-019-12718-0$$gVol. 10, no. 1, p. 4939$$n1$$p4939$$tNature Communications$$v10$$x2041-1723$$y2019
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