000865319 001__ 865319
000865319 005__ 20210130003014.0
000865319 0247_ $$2doi$$a10.1055/s-0039-1683629
000865319 037__ $$aFZJ-2019-04821
000865319 041__ $$aGerman
000865319 1001_ $$0P:(DE-HGF)0$$aApetz, N.$$b0
000865319 1112_ $$a57. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin$$cBremen$$d2019-04-03 - 2019-04-06$$gNuklearMedizin 2019$$wGermany
000865319 245__ $$aModulation of brain network recruitment caused by STN DBS and L-DOPA in parkinsonian rats
000865319 260__ $$c2019
000865319 3367_ $$033$$2EndNote$$aConference Paper
000865319 3367_ $$2DataCite$$aOther
000865319 3367_ $$2BibTeX$$aINPROCEEDINGS
000865319 3367_ $$2DRIVER$$aconferenceObject
000865319 3367_ $$2ORCID$$aLECTURE_SPEECH
000865319 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1569411701_25780$$xAfter Call
000865319 502__ $$cUniversität zu Köln
000865319 520__ $$aZiel/Aim:The unilateral 6-OHDA rat model of Parkinson's disease (PD) is often used to study pathomechanisms and therapeutic effects such as deep brain stimulation (DBS). We established an implantable DBS system to analyse DBS and/or L-DOPA effects on motor behaviour and on cerebral metabolic patterns.Methodik/Methods:Long Evans rats were unilaterally lesioned with 6-OHDA and either received L-DOPA, STN DBS, or a combination of both. [18F]FDG PET scans (uptake normalised to global mean) were used to analyse focal brain activity with (ON) and without (OFF) therapeutic interventions. Motor performance was investigated using the cylinder test.Ergebnisse/Results:Comparing ON and OFF states, L-DOPA and DBS led to different metabolic patterns. DBS increased [18F]FDG uptake mainly ipsilesionally while decreasing it contralesionally, reversing the metabolic imbalance between hemispheres. L-DOPA decreased [18F]FDG uptake bilaterally in the forebrain and increased it in the cerebellum. The latter may indicate increased recruitment of the cerebellum, but may also be explained by cerebral blood flow increases. A combination of DBS and L-DOPA decreased [18F]FDG uptake in the ipsilesional motor cortex and contralesional striatum and increased it in somatosensory cortices, contralesional thalamus and cerebellum. L-DOPA significantly improved contralesional front paw (CF) use, which was impaired during OFF. DBS only caused a slight improvement. A combination of L-DOPA and DBS showed similar results as L-DOPA alone but with higher total values. Continuous DBS for five weeks stabilised and increased the beneficial effects of DBS.Schlussfolgerungen/Conclusions:We conclude that pure reversion of pathologic metabolic imbalances does not seem to be sufficient to improve motor deficits. Rather, the complex recruitment of alternative networks depending on treatment strategy is likely to compensate pathology.
000865319 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000865319 588__ $$aDataset connected to CrossRef Conference
000865319 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, B.$$b1$$ufzj
000865319 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, A.$$b2$$ufzj
000865319 7001_ $$0P:(DE-HGF)0$$aTimmermann, L.$$b3
000865319 7001_ $$0P:(DE-HGF)0$$aEndepols, H.$$b4$$eCorresponding author
000865319 773__ $$a10.1055/s-0039-1683629
000865319 909CO $$ooai:juser.fz-juelich.de:865319$$pVDB
000865319 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)166419$$aForschungszentrum Jülich$$b1$$kFZJ
000865319 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177611$$aForschungszentrum Jülich$$b2$$kFZJ
000865319 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000865319 9141_ $$y2019
000865319 920__ $$lyes
000865319 9201_ $$0I:(DE-Juel1)INM-5-20090406$$kINM-5$$lNuklearchemie$$x0
000865319 9201_ $$0I:(DE-Juel1)INM-2-20090406$$kINM-2$$lMolekulare Organisation des Gehirns$$x1
000865319 980__ $$aconf
000865319 980__ $$aVDB
000865319 980__ $$aI:(DE-Juel1)INM-5-20090406
000865319 980__ $$aI:(DE-Juel1)INM-2-20090406
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