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@INPROCEEDINGS{Apetz:865319,
      author       = {Apetz, N. and Neumaier, B. and Drzezga, A. and Timmermann,
                      L. and Endepols, H.},
      title        = {{M}odulation of brain network recruitment caused by {STN}
                      {DBS} and {L}-{DOPA} in parkinsonian rats},
      school       = {Universität zu Köln},
      reportid     = {FZJ-2019-04821},
      year         = {2019},
      abstract     = {Ziel/Aim:The unilateral 6-OHDA rat model of Parkinson's
                      disease (PD) is often used to study pathomechanisms and
                      therapeutic effects such as deep brain stimulation (DBS). We
                      established an implantable DBS system to analyse DBS and/or
                      L-DOPA effects on motor behaviour and on cerebral metabolic
                      patterns.Methodik/Methods:Long Evans rats were unilaterally
                      lesioned with 6-OHDA and either received L-DOPA, STN DBS, or
                      a combination of both. [18F]FDG PET scans (uptake normalised
                      to global mean) were used to analyse focal brain activity
                      with (ON) and without (OFF) therapeutic interventions. Motor
                      performance was investigated using the cylinder
                      test.Ergebnisse/Results:Comparing ON and OFF states, L-DOPA
                      and DBS led to different metabolic patterns. DBS increased
                      [18F]FDG uptake mainly ipsilesionally while decreasing it
                      contralesionally, reversing the metabolic imbalance between
                      hemispheres. L-DOPA decreased [18F]FDG uptake bilaterally in
                      the forebrain and increased it in the cerebellum. The latter
                      may indicate increased recruitment of the cerebellum, but
                      may also be explained by cerebral blood flow increases. A
                      combination of DBS and L-DOPA decreased [18F]FDG uptake in
                      the ipsilesional motor cortex and contralesional striatum
                      and increased it in somatosensory cortices, contralesional
                      thalamus and cerebellum. L-DOPA significantly improved
                      contralesional front paw (CF) use, which was impaired during
                      OFF. DBS only caused a slight improvement. A combination of
                      L-DOPA and DBS showed similar results as L-DOPA alone but
                      with higher total values. Continuous DBS for five weeks
                      stabilised and increased the beneficial effects of
                      DBS.Schlussfolgerungen/Conclusions:We conclude that pure
                      reversion of pathologic metabolic imbalances does not seem
                      to be sufficient to improve motor deficits. Rather, the
                      complex recruitment of alternative networks depending on
                      treatment strategy is likely to compensate pathology.},
      month         = {Apr},
      date          = {2019-04-03},
      organization  = {57. Jahrestagung der Deutschen
                       Gesellschaft für Nuklearmedizin,
                       Bremen (Germany), 3 Apr 2019 - 6 Apr
                       2019},
      subtyp        = {After Call},
      cin          = {INM-5 / INM-2},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)6},
      doi          = {10.1055/s-0039-1683629},
      url          = {https://juser.fz-juelich.de/record/865319},
}