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@ARTICLE{Zadorozhnyi:865326,
      author       = {Zadorozhnyi, Ihor and Hlukhova, Hanna and Kutovyi, Yurii
                      and Handziuk, Volodymyr and Naumova, Nataliia and
                      Offenhäusser, Andreas and Vitusevich, Svetlana},
      title        = {{T}owards pharmacological treatment screening of
                      cardiomyocyte cells using {S}i nanowire {FET}s},
      journal      = {Biosensors and bioelectronics},
      volume       = {137},
      issn         = {0956-5663},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2019-04828},
      pages        = {229 - 235},
      year         = {2019},
      abstract     = {Silicon nanowires (Si NWs) are the most promising
                      candidates for recording biological signals due to improved
                      interfacing properties with cells and the possibility of
                      high-speed transduction of biochemical signals into
                      detectable electrical responses. The recording of
                      extracellular action potentials (APs) from cardiac cells is
                      important for fundamental studies of AP propagation features
                      reflecting cell activity and the influence of
                      pharmacological substances on the signal. We applied a novel
                      approach of using fabricated Si NW field-effect transistors
                      (FETs) in combination with fluorescent marker techniques to
                      evaluate the functional activity of cardiac cells.
                      Extracellular AP signal recording from HL-1 cardiomyocytes
                      was demonstrated. This method was supplemented by studies of
                      the pharmacological effects of stimulations using
                      noradrenaline (NorA) as a modulator of functional activity
                      on a cellular and subcellular levels, which were also tested
                      using fluorescent marker techniques. The role of calcium
                      alteration and membrane potential were revealed using Fluo-4
                      AM and tetramethylrhodamine, methyl ester, perchlorate
                      (TMRM) fluorescent dyes. In addition, chemical treatment
                      with sodium dodecyl sulfate (SDS) solutions was tested. The
                      results obtained demonstrate positive prospects for AP
                      monitoring in different treatments for studies related to a
                      wide range of myocardial diseases using lab-on-chip
                      technology.},
      cin          = {ICS-8},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31121460},
      UT           = {WOS:000471359200027},
      doi          = {10.1016/j.bios.2019.04.038},
      url          = {https://juser.fz-juelich.de/record/865326},
}