% IMPORTANT: The following is UTF-8 encoded. This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.
@ARTICLE{Zadorozhnyi:865326,
author = {Zadorozhnyi, Ihor and Hlukhova, Hanna and Kutovyi, Yurii
and Handziuk, Volodymyr and Naumova, Nataliia and
Offenhäusser, Andreas and Vitusevich, Svetlana},
title = {{T}owards pharmacological treatment screening of
cardiomyocyte cells using {S}i nanowire {FET}s},
journal = {Biosensors and bioelectronics},
volume = {137},
issn = {0956-5663},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2019-04828},
pages = {229 - 235},
year = {2019},
abstract = {Silicon nanowires (Si NWs) are the most promising
candidates for recording biological signals due to improved
interfacing properties with cells and the possibility of
high-speed transduction of biochemical signals into
detectable electrical responses. The recording of
extracellular action potentials (APs) from cardiac cells is
important for fundamental studies of AP propagation features
reflecting cell activity and the influence of
pharmacological substances on the signal. We applied a novel
approach of using fabricated Si NW field-effect transistors
(FETs) in combination with fluorescent marker techniques to
evaluate the functional activity of cardiac cells.
Extracellular AP signal recording from HL-1 cardiomyocytes
was demonstrated. This method was supplemented by studies of
the pharmacological effects of stimulations using
noradrenaline (NorA) as a modulator of functional activity
on a cellular and subcellular levels, which were also tested
using fluorescent marker techniques. The role of calcium
alteration and membrane potential were revealed using Fluo-4
AM and tetramethylrhodamine, methyl ester, perchlorate
(TMRM) fluorescent dyes. In addition, chemical treatment
with sodium dodecyl sulfate (SDS) solutions was tested. The
results obtained demonstrate positive prospects for AP
monitoring in different treatments for studies related to a
wide range of myocardial diseases using lab-on-chip
technology.},
cin = {ICS-8},
ddc = {610},
cid = {I:(DE-Juel1)ICS-8-20110106},
pnm = {552 - Engineering Cell Function (POF3-552)},
pid = {G:(DE-HGF)POF3-552},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31121460},
UT = {WOS:000471359200027},
doi = {10.1016/j.bios.2019.04.038},
url = {https://juser.fz-juelich.de/record/865326},
}