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@ARTICLE{Krueger:865386,
      author       = {Krueger, Daniel and Quinkler, Theresa and Mortensen, Simon
                      Arnold and Sachse, Carsten and De Renzis, Stefano},
      title        = {{C}ross-linker–mediated regulation of actin network
                      organization controls tissue morphogenesis},
      journal      = {The journal of cell biology},
      volume       = {218},
      number       = {8},
      issn         = {1540-8140},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {FZJ-2019-04871},
      pages        = {2743 - 2761},
      year         = {2019},
      abstract     = {Contraction of cortical actomyosin networks driven by
                      myosin activation controls cell shape changes and tissue
                      morphogenesis during animal development. In vitro studies
                      suggest that contractility also depends on the geometrical
                      organization of actin filaments. Here we analyze the
                      function of actomyosin network topology in vivo using
                      optogenetic stimulation of myosin-II in Drosophila embryos.
                      We show that early during cellularization, hexagonally
                      arrayed actomyosin fibers are resilient to myosin-II
                      activation. Actomyosin fibers then acquire a ring-like
                      conformation and become contractile and sensitive to
                      myosin-II. This transition is controlled by Bottleneck, a
                      Drosophila unique protein expressed for only a short time
                      during early cellularization, which we show regulates actin
                      bundling. In addition, it requires two opposing actin
                      cross-linkers, Filamin and Fimbrin. Filamin acts
                      synergistically with Bottleneck to facilitate hexagonal
                      patterning, while Fimbrin controls remodeling of the
                      hexagonal network into contractile rings. Thus, actin
                      cross-linking regulates the spatio-temporal organization of
                      actomyosin contraction in vivo, which is critical for tissue
                      morphogenesis.},
      cin          = {ER-C-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31253650},
      UT           = {WOS:000478788200021},
      doi          = {10.1083/jcb.201811127},
      url          = {https://juser.fz-juelich.de/record/865386},
}