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@ARTICLE{PetrySchmelzer:865394,
      author       = {Petry-Schmelzer, Jan Niklas and Krause, Max and Dembek,
                      Till A and Horn, Andreas and Evans, Julian and Ashkan,
                      Keyoumars and Rizos, Alexandra and Silverdale, Monty and
                      Schumacher, Wibke and Sack, Carolin and Loehrer, Philipp A
                      and Fink, Gereon R and Fonoff, Erich T and Martinez-Martin,
                      Pablo and Antonini, Angelo and Barbe, Michael T and
                      Visser-Vandewalle, Veerle and Ray-Chaudhuri, K. and
                      Timmermann, Lars and Dafsari, Haidar S},
      title        = {{N}on-motor outcomes depend on location of neurostimulation
                      in {P}arkinson’s disease},
      journal      = {Brain},
      volume       = {142},
      number       = {11},
      issn         = {1460-2156},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2019-04879},
      pages        = {3592-3604},
      year         = {2019},
      abstract     = {Deep brain stimulation of the subthalamic nucleus is an
                      effective and established therapy for patients with advanced
                      Parkinson’s disease improving quality of life, motor
                      symptoms and non-motor symptoms. However, there is a
                      considerable degree of interindividual variability for these
                      outcomes, likely due to variability in electrode placement
                      and stimulation settings. Here, we present probabilistic
                      mapping data from a prospective, open-label, multicentre,
                      international study to investigate the influence of the
                      location of subthalamic nucleus deep brain stimulation on
                      non-motor symptoms in patients with Parkinson’s disease. A
                      total of 91 Parkinson’s disease patients undergoing
                      bilateral deep brain stimulation of the subthalamic nucleus
                      were included, and we investigated NMSScale,
                      NMSQuestionnaire, Scales for Outcomes in Parkinson’s
                      disease-motor examination, -activities of daily living, and
                      -motor complications, and Parkinson’s disease
                      Questionnaire-8 preoperatively and at 6-month follow-up
                      after surgery. Leads were localized in standard space using
                      the Lead-DBS toolbox and individual volumes of tissue
                      activated were calculated based on clinical stimulation
                      settings. Probabilistic stimulation maps and non-parametric
                      permutation statistics were applied to identify voxels with
                      significant above or below average improvement for each
                      scale and analysed using the DISTAL atlas. All outcomes
                      improved significantly at follow-up. Significant spatial
                      distribution patterns of neurostimulation were observed for
                      NMSScale total score and its mood/apathy and
                      attention/memory domains. For both domains, voxels
                      associated with below average improvement were mainly
                      located dorsal to the subthalamic nucleus. In contrast,
                      above average improvement for mood/apathy was observed in
                      the ventral border region of the subthalamic nucleus and in
                      its sensorimotor subregion and for attention/memory in the
                      associative subregion. A trend was observed for NMSScale
                      sleep domain showing voxels with above average improvement
                      located ventral to the subthalamic nucleus. Our study
                      provides evidence that the interindividual variability of
                      mood/apathy, attention/memory, and sleep outcomes after
                      subthalamic nucleus deep brain stimulation depends on the
                      location of neurostimulation. This study highlights the
                      importance of holistic assessments of motor and non-motor
                      aspects of Parkinson’s disease to tailor surgical
                      targeting and stimulation parameter settings to patients’
                      personal profiles.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31553039},
      UT           = {WOS:000504323200034},
      doi          = {10.1093/brain/awz285},
      url          = {https://juser.fz-juelich.de/record/865394},
}