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| Hauptseite > Publikationsdatenbank > Non-motor outcomes depend on location of neurostimulation in Parkinson’s disease > print |
| Hauptseite > Publikationsdatenbank > Non-motor outcomes depend on location of neurostimulation in Parkinson’s disease > print |
| 001 | 865394 | ||
| 005 | 20210130003038.0 | ||
| 024 | 7 | _ | |a 10.1093/brain/awz285 |2 doi |
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| 037 | _ | _ | |a FZJ-2019-04879 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Petry-Schmelzer, Jan Niklas |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Non-motor outcomes depend on location of neurostimulation in Parkinson’s disease |
| 260 | _ | _ | |a Oxford |c 2019 |b Oxford Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Deep brain stimulation of the subthalamic nucleus is an effective and established therapy for patients with advanced Parkinson’s disease improving quality of life, motor symptoms and non-motor symptoms. However, there is a considerable degree of interindividual variability for these outcomes, likely due to variability in electrode placement and stimulation settings. Here, we present probabilistic mapping data from a prospective, open-label, multicentre, international study to investigate the influence of the location of subthalamic nucleus deep brain stimulation on non-motor symptoms in patients with Parkinson’s disease. A total of 91 Parkinson’s disease patients undergoing bilateral deep brain stimulation of the subthalamic nucleus were included, and we investigated NMSScale, NMSQuestionnaire, Scales for Outcomes in Parkinson’s disease-motor examination, -activities of daily living, and -motor complications, and Parkinson’s disease Questionnaire-8 preoperatively and at 6-month follow-up after surgery. Leads were localized in standard space using the Lead-DBS toolbox and individual volumes of tissue activated were calculated based on clinical stimulation settings. Probabilistic stimulation maps and non-parametric permutation statistics were applied to identify voxels with significant above or below average improvement for each scale and analysed using the DISTAL atlas. All outcomes improved significantly at follow-up. Significant spatial distribution patterns of neurostimulation were observed for NMSScale total score and its mood/apathy and attention/memory domains. For both domains, voxels associated with below average improvement were mainly located dorsal to the subthalamic nucleus. In contrast, above average improvement for mood/apathy was observed in the ventral border region of the subthalamic nucleus and in its sensorimotor subregion and for attention/memory in the associative subregion. A trend was observed for NMSScale sleep domain showing voxels with above average improvement located ventral to the subthalamic nucleus. Our study provides evidence that the interindividual variability of mood/apathy, attention/memory, and sleep outcomes after subthalamic nucleus deep brain stimulation depends on the location of neurostimulation. This study highlights the importance of holistic assessments of motor and non-motor aspects of Parkinson’s disease to tailor surgical targeting and stimulation parameter settings to patients’ personal profiles. |
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| 856 | 4 | _ | |y Published on 2019-09-23. Available in OpenAccess from 2020-09-23. |u https://juser.fz-juelich.de/record/865394/files/Petry_Schmelzer_2019_Post%20Print_Brain_Non-motor%20outcomes%20depend%20on%20location%20of%20neurostimulation%20in%20Parkinson%27s%20disease.pdf |
| 856 | 4 | _ | |y Published on 2019-09-23. Available in OpenAccess from 2020-09-23. |x pdfa |u https://juser.fz-juelich.de/record/865394/files/Petry_Schmelzer_2019_Post%20Print_Brain_Non-motor%20outcomes%20depend%20on%20location%20of%20neurostimulation%20in%20Parkinson%27s%20disease.pdf?subformat=pdfa |
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