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@INPROCEEDINGS{Pauli:865532,
      author       = {Pauli, Robin and Morrison, Abigail and Tetzlaff, Tom},
      title        = {{L}ocalization of coherent activity based on
                      multi-electrode local field potentials},
      reportid     = {FZJ-2019-04916},
      year         = {2019},
      abstract     = {Deep brain stimulation (DBS) of the subthalamic nucleus
                      (STN) is an established method for the suppression of motor
                      deficits in Parkinson's disease. The efficacy and the extent
                      of side effects of DBS depend critically on the positioning
                      of the stimulation electrode. In particular with the
                      increased use of directional DBS, it is becoming more
                      difficult to find optimal stimulation parameters. A major
                      challenge during the positioning of DBS electrodes is the
                      detection of hotspots associated with the generation of
                      pathological coherent activity. Here, we develop and test a
                      method aiming at localizing confined regions of coherent
                      activity based on the local field potential (LFP) recorded
                      with multiple electrodes (see figure). Our approach involves
                      two steps, the identification of coherent sources by
                      independent-component analysis of the multi-channel
                      recordings in Fourier space, and the localization of
                      identified sources by means of current-source-density
                      analysis. We benchmark this technique for a range of source
                      sizes and source-electrode distances based on synthetic
                      ground-truth data generated by multicompartment models of
                      STN neurons with realistic morphology. In this framework, we
                      show that the spatio-temporal structure of the LFP recorded
                      with multiple electrodes can be exploited to achieve a
                      localization precision exceeding the spatial resolution of
                      the electrode configuration. The proposed method permits a
                      continuous tracking of source positions and may therefore
                      provide a tool to study the spatio-temporal organization of
                      pathological activity in STN. Moreover, it could serve as an
                      intra-operative guide for the positioning of DBS electrodes
                      and thereby improve and speed up the implantation process
                      and the adjustment of stimulus parameters.},
      month         = {Sep},
      date          = {2019-09-17},
      organization  = {Bernstein Conference 2019, Berlin
                       (Germany), 17 Sep 2019 - 20 Sep 2019},
      subtyp        = {After Call},
      cin          = {INM-6 / IAS-6 / INM-10},
      cid          = {I:(DE-Juel1)INM-6-20090406 / I:(DE-Juel1)IAS-6-20130828 /
                      I:(DE-Juel1)INM-10-20170113},
      pnm          = {574 - Theory, modelling and simulation (POF3-574) / 572 -
                      (Dys-)function and Plasticity (POF3-572) / DFG project
                      233510988 - Mathematische Modellierung der Entstehung und
                      Suppression pathologischer Aktivitätszustände in den
                      Basalganglien-Kortex-Schleifen (233510988) / HBP SGA1 -
                      Human Brain Project Specific Grant Agreement 1 (720270) /
                      HBP SGA2 - Human Brain Project Specific Grant Agreement 2
                      (785907) / Advanced Computing Architectures $(aca_20190115)$
                      / PhD no Grant - Doktorand ohne besondere Förderung
                      (PHD-NO-GRANT-20170405)},
      pid          = {G:(DE-HGF)POF3-574 / G:(DE-HGF)POF3-572 /
                      G:(GEPRIS)233510988 / G:(EU-Grant)720270 /
                      G:(EU-Grant)785907 / $G:(DE-Juel1)aca_20190115$ /
                      G:(DE-Juel1)PHD-NO-GRANT-20170405},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/865532},
}