%0 Journal Article
%A Baldermann, Juan
%A Hahn, Lisa
%A Dembek, Till
%A Kohl, Sina
%A Kuhn, Jens
%A Visser-Vandewalle, Veerle
%A Horn, Andreas
%A Huys, Daniel
%T Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
%J Brain Sciences
%V 9
%N 10
%@ 2076-3425
%C Basel
%I MDPI AG
%M FZJ-2019-04956
%P 264
%D 2019
%Z Financial disclosuresThis work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, KFO-219 Grant, KU2665/1-2 to JK). TD has received speaker honoraria from Boston Scientific and Medtronic. JK has received financial support for Investigator initiated trials from Medtronic. VV-V has received payments for travelling, lodging and financial compensation for contributions to advisory boards or workshops (mostly 2/year) by Medtronic, Abbott and St. Jude Medical.
%X Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31623328
%U <Go to ISI:>//WOS:000493515400036
%R 10.3390/brainsci9100264
%U https://juser.fz-juelich.de/record/865600