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000865600 1001_ $$0P:(DE-HGF)0$$aBaldermann, Juan$$b0$$eCorresponding author
000865600 245__ $$aWeight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
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000865600 500__ $$aFinancial disclosuresThis work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, KFO-219 Grant, KU2665/1-2 to JK). TD has received speaker honoraria from Boston Scientific and Medtronic. JK has received financial support for Investigator initiated trials from Medtronic. VV-V has received payments for travelling, lodging and financial compensation for contributions to advisory boards or workshops (mostly 2/year) by Medtronic, Abbott and St. Jude Medical.
000865600 520__ $$aWeight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential
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000865600 7001_ $$0P:(DE-Juel1)177012$$aHahn, Lisa$$b1
000865600 7001_ $$00000-0001-7023-146X$$aDembek, Till$$b2
000865600 7001_ $$0P:(DE-HGF)0$$aKohl, Sina$$b3
000865600 7001_ $$0P:(DE-HGF)0$$aKuhn, Jens$$b4
000865600 7001_ $$0P:(DE-HGF)0$$aVisser-Vandewalle, Veerle$$b5
000865600 7001_ $$00000-0002-0695-6025$$aHorn, Andreas$$b6
000865600 7001_ $$0P:(DE-HGF)0$$aHuys, Daniel$$b7
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