TY  - JOUR
AU  - Baldermann, Juan
AU  - Hahn, Lisa
AU  - Dembek, Till
AU  - Kohl, Sina
AU  - Kuhn, Jens
AU  - Visser-Vandewalle, Veerle
AU  - Horn, Andreas
AU  - Huys, Daniel
TI  - Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus
JO  - Brain Sciences
VL  - 9
IS  - 10
SN  - 2076-3425
CY  - Basel
PB  - MDPI AG
M1  - FZJ-2019-04956
SP  - 264
PY  - 2019
N1  - Financial disclosuresThis work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, KFO-219 Grant, KU2665/1-2 to JK). TD has received speaker honoraria from Boston Scientific and Medtronic. JK has received financial support for Investigator initiated trials from Medtronic. VV-V has received payments for travelling, lodging and financial compensation for contributions to advisory boards or workshops (mostly 2/year) by Medtronic, Abbott and St. Jude Medical.
AB  - Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential
LB  - PUB:(DE-HGF)16
C6  - pmid:31623328
UR  - <Go to ISI:>//WOS:000493515400036
DO  - DOI:10.3390/brainsci9100264
UR  - https://juser.fz-juelich.de/record/865600
ER  -