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@ARTICLE{Baldermann:865600,
      author       = {Baldermann, Juan and Hahn, Lisa and Dembek, Till and Kohl,
                      Sina and Kuhn, Jens and Visser-Vandewalle, Veerle and Horn,
                      Andreas and Huys, Daniel},
      title        = {{W}eight {C}hange after {S}triatal/{C}apsule {D}eep {B}rain
                      {S}timulation {R}elates to {C}onnectivity to the {B}ed
                      {N}ucleus of the {S}tria {T}erminalis and {H}ypothalamus},
      journal      = {Brain Sciences},
      volume       = {9},
      number       = {10},
      issn         = {2076-3425},
      address      = {Basel},
      publisher    = {MDPI AG},
      reportid     = {FZJ-2019-04956},
      pages        = {264},
      year         = {2019},
      note         = {Financial disclosuresThis work was supported by the German
                      Research Foundation (Deutsche Forschungsgemeinschaft,
                      KFO-219 Grant, KU2665/1-2 to JK). TD has received speaker
                      honoraria from Boston Scientific and Medtronic. JK has
                      received financial support for Investigator initiated trials
                      from Medtronic. VV-V has received payments for travelling,
                      lodging and financial compensation for contributions to
                      advisory boards or workshops (mostly 2/year) by Medtronic,
                      Abbott and St. Jude Medical.},
      abstract     = {Weight changes are insufficiently understood adverse events
                      of deep brain stimulation. In this context, exploring neural
                      networks of weight control may inform novel treatment
                      strategies for weight-related disorders. In this study, we
                      investigated weight changes after deep brain stimulation of
                      the ventral striatum/ventral capsule and to what extent
                      changes are associated with connectivity to feeding-related
                      networks. We retrospectively analyzed 25 patients undergoing
                      deep brain stimulation for obsessive-compulsive disorder or
                      substance dependency. Weight changes were assessed
                      preoperatively and six to twelve months after surgery and
                      then matched with individual stimulation sites and
                      stimulation-dependent functional connectivity to a priori
                      defined regions of interest that are involved in food
                      intake. We observed a significant weight gain after six to
                      twelve months of continuous stimulation. Weight increases
                      were associated with medial/apical localization of
                      stimulation sites and with connectivity to hypothalamic
                      areas and the bed nucleus. Thus, deep brain stimulation of
                      the ventral striatum/ventral capsule influences weight
                      depending on localization and connectivity of stimulation
                      sites. Bearing in mind the significance of weight-related
                      disorders, we advocate further prospective studies
                      investigating the neuroanatomical and neuropsychological
                      underpinnings of food intake and their neuromodulatory
                      therapeutic potential},
      cin          = {INM-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {574 - Theory, modelling and simulation (POF3-574)},
      pid          = {G:(DE-HGF)POF3-574},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31623328},
      UT           = {WOS:000493515400036},
      doi          = {10.3390/brainsci9100264},
      url          = {https://juser.fz-juelich.de/record/865600},
}