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| Home > Publications database > Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus > print |
| Home > Publications database > Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus > print |
| 001 | 865600 | ||
| 005 | 20210130003102.0 | ||
| 024 | 7 | _ | |a 10.3390/brainsci9100264 |2 doi |
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| 100 | 1 | _ | |a Baldermann, Juan |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus |
| 260 | _ | _ | |a Basel |c 2019 |b MDPI AG |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a Financial disclosuresThis work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, KFO-219 Grant, KU2665/1-2 to JK). TD has received speaker honoraria from Boston Scientific and Medtronic. JK has received financial support for Investigator initiated trials from Medtronic. VV-V has received payments for travelling, lodging and financial compensation for contributions to advisory boards or workshops (mostly 2/year) by Medtronic, Abbott and St. Jude Medical. |
| 520 | _ | _ | |a Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential |
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| 700 | 1 | _ | |a Kuhn, Jens |0 P:(DE-HGF)0 |b 4 |
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| 700 | 1 | _ | |a Huys, Daniel |0 P:(DE-HGF)0 |b 7 |
| 773 | _ | _ | |a 10.3390/brainsci9100264 |g Vol. 9, no. 10, p. 264 - |0 PERI:(DE-600)2651993-8 |n 10 |p 264 |t Brain Sciences |v 9 |y 2019 |x 2076-3425 |
| 856 | 4 | _ | |y OpenAccess |u https://juser.fz-juelich.de/record/865600/files/brainsci-09-00264-v2.pdf |
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