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@ARTICLE{Walz:865633,
      author       = {Walz, Olga and Djelassi, Hatim and Mitsos, Alexander},
      title        = {{O}ptimal experimental design for optimal process design:
                      {A} trilevel optimization formulation},
      journal      = {AIChE journal},
      volume       = {66},
      number       = {1},
      issn         = {0001-1541},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {FZJ-2019-04984},
      pages        = {e16788},
      year         = {2020},
      abstract     = {Typical optimal experimental design (OED) methods aim at
                      minimizing the covariance matrix of the estimated parameters
                      regardless of the intended application of the model that is
                      being estimated. This can unnecessarily increase the
                      experimental costs. Herein, we propose a new OED method,
                      which tailors the designed experiments to the model
                      application. The method is demonstrated for model‐based
                      process design and aims at mitigating a worst‐case
                      realization of the process design. The proposed formulation
                      results in a min–max–min problem and is based on
                      bounded‐error OED. The method is illustrated via an ad hoc
                      solution method using two examples, a simple illustrative
                      example and the van de Vusse reaction, that show the
                      differences between typical and the new tailored OED method:
                      experimental designs can be considered good using the latter
                      method, while the same design would be considered bad with
                      the former methods.},
      cin          = {IEK-10},
      ddc          = {660},
      cid          = {I:(DE-Juel1)IEK-10-20170217},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000488268000001},
      doi          = {10.1002/aic.16788},
      url          = {https://juser.fz-juelich.de/record/865633},
}