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@ARTICLE{Adhikari:865828,
      author       = {Adhikari, Bhim M. and Dukart, Juergen and Hipp, Joerg F.
                      and Forsyth, Anna and McMillan, Rebecca and
                      Muthukumaraswamy, Suresh D. and Ryan, Meghann C. and Elliot
                      Hong, L. and Eickhoff, Simon and Jahanshad, Neda and
                      Thompson, Paul M. and Rowland, Laura M. and Kochunov, Peter},
      title        = {{E}ffects of {K}etamine and {M}idazolam on resting state
                      connectivity and comparison with {ENIGMA} connectivity
                      deficit patterns in schizophrenia},
      journal      = {Human brain mapping},
      volume       = {41},
      number       = {3},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2019-05119},
      pages        = {767-778},
      year         = {2020},
      note         = {NIH. Grant Numbers: T32MH067533, R01MH085646, R01DA027680,
                      R01MH112180, R01EB015611, U01MH108148, U54EB020403},
      abstract     = {Subanesthetic administration of ketamine is a
                      pharmacological model to elicit positiveand negative
                      symptoms of psychosis in healthy volunteers. We used resting
                      statepharmacological functional MRI (rsPhfMRI) to identify
                      cerebral networks affected by ketamineand compared them to
                      the functional connectivity (FC) in schizophrenia. Ketamine
                      can producesedation and we contrasted its effects with the
                      effects of the anxiolytic drug midazolam.Thirty healthy male
                      volunteers (age=19-37 years) underwent a randomized,
                      three-way,cross-over study consisting of three imaging
                      sessions, with 48 hours between sessions. A sessionconsisted
                      of a control period followed by infusion of placebo or
                      ketamine or midazolam. TheENIGMA rsfMRI pipeline was used to
                      derive two long distance (seed-based and dualregression)and
                      one local (regional homogeneity, ReHo) FC measures. Ketamine
                      inducedsignificant reductions in the connectivity of the
                      salience network (Cohen’s d:1.13±0.28,p=4.0×10-3),
                      auditory network (d: 0.67±0.26, p=0.04) and default mode
                      network (DMN,d:0.63±0.26, p=0.05). Midazolam significantly
                      reduced connectivity in the DMN (d:0.77±0.27,p=0.03). The
                      effect sizes for ketamine for resting networks showed a
                      positive correlation(r=0.59, p=0.07) with the effect sizes
                      for schizophrenia related deficits derived from
                      ENIGMA’sstudy of 261 patients and 327 controls. Effect
                      sizes for midazolam were not correlated with
                      theschizophrenia pattern (r=-0.17, p=0.65). The subtraction
                      of ketamine and midazolam patternsshowed a significant
                      positive correlation with the pattern of schizophrenia
                      deficits (r=0.68,p=0.03).RsPhfMRI reliably detected the
                      shared and divergent pharmacological actions ofketamine and
                      midazolam on cerebral networks. The pattern of
                      disconnectivity produced byketamine was positively
                      correlated with the pattern of connectivity deficits
                      observed inschizophrenia, suggesting a brain functional
                      basis for previously poorly understood effects of thedrug.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {573 - Neuroimaging (POF3-573) / 571 - Connectivity and
                      Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-573 / G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31633254},
      UT           = {WOS:000491156400001},
      doi          = {10.1002/hbm.24838},
      url          = {https://juser.fz-juelich.de/record/865828},
}