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000865876 1001_ $$0P:(DE-HGF)0$$aLebedev, Dmitry V.$$b0
000865876 245__ $$aEffect of alpha-lactalbumin and lactoferrin oleic acid complexes on chromatin structural organization
000865876 260__ $$aOrlando, Fla.$$bAcademic Press$$c2019
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000865876 520__ $$aThis work focuses on the study of multimeric alpha-lactalbumin oleic acid and lactoferrin oleic acid complexes. The purpose of the research is to study possible mechanisms involved in their pro-apoptotic activities, as seen in some tumor cell cultures. Complexes featuring oleic acid (OA) with human alpha-lactalbumin (hAl) or with bovine alpha-lactalbumin (bAl), and human lactoferrin (hLf) were investigated using small-angle neutron scattering (SANS). It was shown that while alpha-lactalbumin protein complexes were formed on the surface of polydisperse OA micelles, the lactoferrin complexes comprised a monodisperse system of nanoscale particles. Both hAl and hLf complexes appeared to interact with the chromatin of isolated nuclei affecting chromatin structural organization. The possible roles of these processes in the specific anti-tumor activity of these complexes are discussed.
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000865876 7001_ $$00000-0003-2012-9461$$aZabrodskaya, Yana A.$$b1$$eCorresponding author
000865876 7001_ $$0P:(DE-Juel1)130893$$aPipich, Vitaliy$$b2$$ufzj
000865876 7001_ $$0P:(DE-HGF)0$$aKuklin, Alexander I.$$b3
000865876 7001_ $$0P:(DE-HGF)0$$aRamsay, Edward$$b4
000865876 7001_ $$0P:(DE-HGF)0$$aSokolov, Alexey V.$$b5
000865876 7001_ $$0P:(DE-HGF)0$$aElizarova, Anna Yu$$b6
000865876 7001_ $$0P:(DE-HGF)0$$aShaldzhyan, Aram A.$$b7
000865876 7001_ $$0P:(DE-HGF)0$$aGrudinina, Natalia A.$$b8
000865876 7001_ $$0P:(DE-HGF)0$$aPantina, Rimma A.$$b9
000865876 7001_ $$0P:(DE-Juel1)151161$$aWu, Baohu$$b10
000865876 7001_ $$0P:(DE-HGF)0$$aShtam, Tatiana A.$$b11
000865876 7001_ $$0P:(DE-HGF)0$$aVolnitskiy, Andrey V.$$b12
000865876 7001_ $$0P:(DE-HGF)0$$aSchmidt, Alexander E.$$b13
000865876 7001_ $$0P:(DE-HGF)0$$aShvetsov, Alexey V.$$b14
000865876 7001_ $$0P:(DE-HGF)0$$aVasilyev, Vadim B.$$b15
000865876 7001_ $$0P:(DE-HGF)0$$aIsaev-Ivanov, Vladimir V.$$b16
000865876 7001_ $$0P:(DE-HGF)0$$aEgorov, Vladimir V.$$b17
000865876 773__ $$0PERI:(DE-600)1461396-7$$a10.1016/j.bbrc.2019.09.116$$gVol. 520, no. 1, p. 136 - 139$$n1$$p136 - 139$$tBiochemical and biophysical research communications$$v520$$x0006-291X$$y2019
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