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@ARTICLE{Iashina:865919,
      author       = {Iashina, Ekaterina G. and Filatov, Mikhail V. and Pantina,
                      Rimma A. and Varfolomeeva, Elena Yu. and Bouwman, Wim G. and
                      Duif, Chris P. and Honecker, Dirk and Pipich, Vitaliy and
                      Grigoriev, Sergey V.},
      title        = {{S}mall-angle neutron scattering ({SANS}) and spin-echo
                      {SANS} measurements reveal the logarithmic fractal structure
                      of the large-scale chromatin organization in {H}e{L}a
                      nuclei},
      journal      = {Journal of applied crystallography},
      volume       = {52},
      number       = {4},
      issn         = {1600-5767},
      address      = {[S.l.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2019-05196},
      pages        = {844 - 853},
      year         = {2019},
      abstract     = {This paper reports on the two-scale fractal structure of
                      chromatin organization in the nucleus of the HeLa cell. Two
                      neutron scattering methods, small-angle neutron scattering
                      (SANS) and spin-echo SANS, are used to unambiguously
                      identify the large-scale structure as being a logarithmic
                      fractal with the correlation function γ(r) ∼ ln(r/ξ).
                      The smaller-scale structural level is shown to be a volume
                      fractal with dimension DF = 2.41. By definition, the volume
                      fractal is self-similar at different scales, while the
                      logarithmic fractal is hierarchically changed upon scaling.
                      As a result, the logarithmic fractal is more compact than
                      the volume fractal but still has a rather high surface area,
                      which provides accessibility at all length scales.
                      Apparently such bi-fractal chromatin organization is the
                      result of an evolutionary process of optimizing the
                      compactness and accessibility of gene packing. As they are
                      in a water solution, the HeLa nuclei tend to agglomerate
                      over time. The large-scale logarithmic fractal structure of
                      chromatin provides the HeLa nucleus with the possibility of
                      penetrating deeply into the adjacent nucleus during the
                      agglomeration process. The interpenetration phenomenon of
                      the HeLa nuclei shows that the chromatin-free space of one
                      nucleus is not negligible but is as large as the volume
                      occupied by chromatin itself. It is speculated that it is
                      the logarithmic fractal architecture of chromatin that
                      provides a comfortable compartment for this most important
                      function of the cell.},
      cin          = {JCNS-FRM-II / JCNS-1 / MLZ},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-588b)4597118-3},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS3-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000477717400017},
      doi          = {10.1107/S160057671900921X},
      url          = {https://juser.fz-juelich.de/record/865919},
}