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000865920 1001_ $$0P:(DE-HGF)0$$aIashina, E. G.$$b0$$eCorresponding author
000865920 245__ $$aLarge-Scale Structure of Chromatin: A Fractal Globule or a Logarithmic Fractal?
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000865920 520__ $$aTwo physical models are considered to describe the large-scale structure of chromatin in the nucleus of a biological cell in the interphase state: a fractal globule model and a logarithmic fractal model. Based on the classification of fractal objects developed by the small-angle neutron scattering (SANS) method, it is shown that the fractal globule model does not satisfy the experimental data on small-angle neutron scattering by the nuclei of biological cells. Conversely, the logarithmic fractal model well describes the experimental data on SANS and, hence, provides a good approximation to describe the large-scale structure of chromatin. The logarithmic fractal model predicts that the nuclear space is exactly half-filled with chromatin, and the second half consists of interchromatin voids filled with nucleoplasma in which various nuclear processes occur. Thus, two opposing trends are balanced in the structural organization of chromatin: an increase in the surface area of chromatin in the cell nucleus (accessibility to external agents) and a decrease in the volume occupied by chromatin (compactness of the nucleus).
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000865920 7001_ $$0P:(DE-HGF)0$$aGrigoriev, S. V.$$b1
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