TY  - JOUR
AU  - Iashina, E. G.
AU  - Grigoriev, S. V.
TI  - Large-Scale Structure of Chromatin: A Fractal Globule or a Logarithmic Fractal?
JO  - Journal of experimental and theoretical physics
VL  - 129
IS  - 3
SN  - 1090-6509
CY  - Heidelberg [u.a.]
PB  - Springer
M1  - FZJ-2019-05197
SP  - 455 - 458
PY  - 2019
AB  - Two physical models are considered to describe the large-scale structure of chromatin in the nucleus of a biological cell in the interphase state: a fractal globule model and a logarithmic fractal model. Based on the classification of fractal objects developed by the small-angle neutron scattering (SANS) method, it is shown that the fractal globule model does not satisfy the experimental data on small-angle neutron scattering by the nuclei of biological cells. Conversely, the logarithmic fractal model well describes the experimental data on SANS and, hence, provides a good approximation to describe the large-scale structure of chromatin. The logarithmic fractal model predicts that the nuclear space is exactly half-filled with chromatin, and the second half consists of interchromatin voids filled with nucleoplasma in which various nuclear processes occur. Thus, two opposing trends are balanced in the structural organization of chromatin: an increase in the surface area of chromatin in the cell nucleus (accessibility to external agents) and a decrease in the volume occupied by chromatin (compactness of the nucleus).
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000491494700017
DO  - DOI:10.1134/S106377611908017X
UR  - https://juser.fz-juelich.de/record/865920
ER  -