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@MASTERSTHESIS{Kraljevic:865944,
      author       = {Kraljevic, Nevena},
      title        = {{P}henotypic and {G}enetic {C}orrelation of {C}ognition,
                      {A}ffect, and {B}rain {M}orphometry},
      school       = {Heinrich-Heine Universität Düsseldorf},
      type         = {Masterarbeit},
      reportid     = {FZJ-2019-05210},
      pages        = {85},
      year         = {2019},
      note         = {Masterarbeit, Heinrich-Heine Universität Düsseldorf,
                      2019},
      abstract     = {Background: Cognition is marked by complex cognitive
                      processes and can be quantifiedusing intelligence
                      constructs. On the other hand, affect is an indistinct
                      construct,seemingly happening subconsciously and difficult
                      to quantify (Newell $\&$ Shanks, 2014;Tamietto $\&$ de
                      Gelder, 2010). A large body of evidence has shown that
                      cognition isheritable and relates to brain structure (Devlin
                      et al., 1997; Krapohl et al., 2014). Indeed,studies have
                      shown that co-variation of cognition and brain structure is
                      driven by sharedadditive genetic effects (Toga $\&$
                      Thompson, 2005). Contrary to this, little is known aboutthe
                      genetic basis of affective behavior. The current study
                      investigates how cognition hasa phenotypic and genetic
                      correlation with emotion processing, and positive and
                      negativeaffect, and whether these aptitudes relate to
                      similar brain regions.Methods: Using a large sample of
                      healthy individuals based on the open access twindesignof
                      the Human Connectome Project, phenotypic correlation and
                      heritability and coheritabilityof cognitive abilities,
                      emotion processing, and positive and negative affectwere
                      tested using SOLAR-Eclipse. Following, these aptitudes were
                      correlated to corticalthickness, using a 200 parcel-based
                      approach (Schaefer et al., 2018) to summarizeindividual
                      differences in grey-matter structure in the cortex. Last,
                      the genetic correlationbetween total cognitive score,
                      emotion processing, and positive and negative affect on
                      onehand, and cortical thickness on the other was
                      assessed.Results: Behaviorally, a positive phenotypic
                      correlation of cognitive abilities with bothsuccessful
                      emotion processing and positive affect was observed. The
                      positive correlationbetween cognitive abilities and emotion
                      processing was shown to be driven by additivegenetic
                      effects. At the brain level, phenotypic and genetic
                      correlation between cognitionand affect was strongest in the
                      dorsolateral prefrontal cortex. Positive affect
                      additionallyshowed phenotypic correlation in occipital and
                      parietal lobe. In sum, this study pointstoward a shared
                      genetic basis of cognition and affect, anchored in the
                      dorsolateralprefrontal cortex.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {574 - Theory, modelling and simulation (POF3-574)},
      pid          = {G:(DE-HGF)POF3-574},
      typ          = {PUB:(DE-HGF)19},
      doi          = {10.34734/FZJ-2019-05210},
      url          = {https://juser.fz-juelich.de/record/865944},
}