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@ARTICLE{Glanville:865949,
author = {Glanville, Kylie P and Coleman, Jonathan R I and Hanscombe,
Ken B and Euesden, Jack and Choi, Shing Wan and Purves,
Kirstin L and Breen, Gerome and Air, Tracy M and Andlauer,
Till F M and Baune, Bernhard T and Binder, Elisabeth B and
Blackwood, Douglas H R and Boomsma, Dorret I and
Buttenschøn, Henriette N and Colodro-Conde, Lucía and
Dannlowski, Udo and Direk, Nese and Dunn, Erin C and
Forstner, Andreas J and de Geus, Eco J C and Grabe, Hans J
and Hamilton, Steven P and Jones, Ian and Jones, Lisa A and
Knowles, James A and Kutalik, Zoltán and Levinson, Douglas
F and Lewis, Glyn and Lind, Penelope A and Lucae, Susanne
and Magnusson, Patrik K and McGuffin, Peter and McIntosh,
Andrew M and Milaneschi, Yuri and Mors, Ole and Mostafavi,
Sara and Müller-Myhsok, Bertram and Pedersen, Nancy L and
Penninx, Brenda W J H and Potash, James B and Preisig,
Martin and Ripke, Stephan and Shi, Jianxin and Shyn, Stanley
I and Smoller, Jordan W and Streit, Fabian and Sullivan,
Patrick F and Tiemeier, Henning and Uher, Rudolf and Van der
Auwera, Sandra and Weissman, Myrna M and Consortium, Major
Depressive Disorder Working Group of the Psychiatric
Genomics and O'Reilly, Paul F and Lewis, Cathryn M and Wray,
Naomi R and Ripke, Stephan and Mattheisen, Manuel and
Trzaskowski, Maciej and Byrne, Enda M and Abdellaoui, Abdel
and Adams, Mark J and Agerbo, Esben and Air, Tracy M and
Andlauer, Till F M and Bacanu, Silviu-Alin and
Bækvad-Hansen, Marie and Beekman, Aartjan T F and Bigdeli,
Tim B and Binder, Elisabeth B and Bryois, Julien and
Buttenschøn, Henriette N and Bybjerg-Grauholm, Jonas and
Cai, Na and Castelao, Enrique and Christensen, Jane
Hvarregaard and Clarke, Toni-Kim and Coleman, Jonathan R I
and Colodro-Conde, Lucía and Couvy-Duchesne, Baptiste and
Craddock, Nick and Crawford, Gregory E and Davies, Gail and
Deary, Ian J and Degenhardt, Franziska and Derks, Eske M and
Direk, Nese and Dolan, Conor V and Dunn, Erin C and Eley,
Thalia C and Escott-Price, Valentina and Hassan Kiadeh,
Farnush Farhadi and Finucane, Hilary K and Foo, Jerome C and
Forstner, Andreas J and Frank, Josef and Gaspar, Héléna A
and Gill, Michael and Goes, Fernando S and Gordon, Scott D
and Grove, Jakob and Hall, Lynsey S and Hansen, Christine
Søholm and Hansen, Thomas F and Herms, Stefan and Hickie,
Ian B and Hoffmann, Per and Homuth, Georg and Horn, Carsten
and Hottenga, Jouke-Jan and Hougaard, David M and Howard,
David M and Ising, Marcus and Jansen, Rick and Jones, Ian
and Jones, Lisa A and Jorgenson, Eric and Knowles, James A
and Kohane, Isaac S and Kraft, Julia and Kretzschmar, Warren
W and Kutalik, Zoltán and Li, Yihan and Lind, Penelope A
and MacIntyre, Donald J and MacKinnon, Dean F and Maier,
Robert M and Maier, Wolfgang and Marchini, Jonathan and
Mbarek, Hamdi and McGrath, Patrick and McGuffin, Peter and
Medland, Sarah E and Mehta, Divya and Middeldorp, Christel M
and Mihailov, Evelin and Milaneschi, Yuri and Milani, Lili
and Mondimore, Francis M and Montgomery, Grant W and
Mostafavi, Sara and Mullins, Niamh and Nauck, Matthias and
Ng, Bernard and Nivard, Michel G and Nyholt, Dale R and
O'Reilly, Paul F and Oskarsson, Hogni and Owen, Michael J
and Painter, Jodie N and Pedersen, Carsten Bøcker and
Pedersen, Marianne Giørtz and Peterson, Roseann E and
Pettersson, Erik and Peyrot, Wouter J and Pistis, Giorgio
and Posthuma, Danielle and Quiroz, Jorge A and Qvist, Per
and Rice, John P and Riley, Brien P and Rivera, Margarita
and Mirza, Saira Saeed and Schoevers, Robert and Schulte,
Eva C and Shen, Ling and Shi, Jianxin and Shyn, Stanley I
and Sigurdsson, Engilbert and Sinnamon, Grant C B and Smit,
Johannes H and Smith, Daniel J and Stefansson, Hreinn and
Steinberg, Stacy and Streit, Fabian and Strohmaier, Jana and
Tansey, Katherine E and Teismann, Henning and Teumer,
Alexander and Thompson, Wesley and Thomson, Pippa A and
Thorgeirsson, Thorgeir E and Traylor, Matthew and Treutlein,
Jens and Trubetskoy, Vassily and Uitterlinden, Andrés G and
Umbricht, Daniel and Van der Auwera, Sandra and van Hemert,
Albert M and Viktorin, Alexander and Visscher, Peter M and
Wang, Yunpeng and Webb, Bradley T and Weinsheimer, Shantel
Marie and Wellmann, Jürgen and Willemsen, Gonneke and Witt,
Stephanie H and Wu, Yang and Xi, Hualin S and Yang, Jian and
Zhang, Futao and Arolt, Volker and Baune, Bernhard T and
Berger, Klaus and Boomsma, Dorret I and Cichon, Sven and
Dannlowski, Udo and de Geus, E. J. C. and DePaulo, J Raymond
and Domenici, Enrico and Domschke, Katharina and Esko, Tõnu
and Grabe, Hans J and Hamilton, Steven P and Hayward,
Caroline and Heath, Andrew C and Kendler, Kenneth S and
Kloiber, Stefan and Lewis, Glyn and Li, Qingqin S and Lucae,
Susanne and Madden, Pamela Af and Magnusson, Patrik K and
Martin, Nicholas G and McIntosh, Andrew M and Metspalu,
Andres and Mors, Ole and Mortensen, Preben Bo and
Müller-Myhsok, Bertram and Nordentoft, Merete and Nöthen,
Markus M and O'Donovan, Michael C and Paciga, Sara A and
Pedersen, Nancy L and Penninx, Brenda W J H and Perlis, Roy
H and Porteous, David J and Potash, James B and Preisig,
Martin and Rietschel, Marcella and Schaefer, Catherine and
Schulze, Thomas G and Smoller, Jordan W and Stefansson, Kari
and Tiemeier, Henning and Uher, Rudolf and Völzke, Henry
and Weissman, Myrna M and Werge, Thomas and Lewis, Cathryn M
and Levinson, Douglas F and Breen, Gerome and Børglum,
Anders D and Sullivan, Patrick F},
title = {{C}lassical {H}uman {L}eukocyte {A}ntigen {A}lleles and
{C}4 {H}aplotypes {A}re {N}ot {S}ignificantly {A}ssociated
{W}ith {D}epression.},
journal = {Biological psychiatry},
volume = {87},
number = {5},
issn = {0006-3223},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2019-05215},
pages = {419-430},
year = {2020},
abstract = {The prevalence of depression is higher in individuals with
autoimmune diseases, but the mechanisms underlying the
observed comorbidities are unknown. Shared genetic etiology
is a plausible explanation for the overlap, and in this
study we tested whether genetic variation in the major
histocompatibility complex (MHC), which is associated with
risk for autoimmune diseases, is also associated with risk
for depression.We fine-mapped the classical MHC (chr6:
29.6-33.1 Mb), imputing 216 human leukocyte antigen (HLA)
alleles and 4 complement component 4 (C4) haplotypes in
studies from the Psychiatric Genomics Consortium Major
Depressive Disorder Working Group and the UK Biobank. The
total sample size was 45,149 depression cases and 86,698
controls. We tested for association between depression
status and imputed MHC variants, applying both a region-wide
significance threshold (3.9 × 10-6) and a candidate
threshold (1.6 × 10-4).No HLA alleles or C4 haplotypes
were associated with depression at the region-wide
threshold. HLA-B*08:01 was associated with modest protection
for depression at the candidate threshold for testing in HLA
genes in the meta-analysis (odds ratio = 0.98, $95\%$
confidence interval = 0.97-0.99).We found no evidence that
an increased risk for depression was conferred by HLA
alleles, which play a major role in the genetic
susceptibility to autoimmune diseases, or C4 haplotypes,
which are strongly associated with schizophrenia. These
results suggest that any HLA or C4 variants associated with
depression either are rare or have very modest effect
sizes.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31570195},
UT = {WOS:000511835600008},
doi = {10.1016/j.biopsych.2019.06.031},
url = {https://juser.fz-juelich.de/record/865949},
}
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