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@ARTICLE{Tscherpel:865951,
      author       = {Tscherpel, Caroline and Hensel, Lukas and Lemberg,
                      Katharina and Freytag, Jana and Michely, Jochen and Volz,
                      Lukas J. and Fink, Gereon R. and Grefkes, Christian},
      title        = {{A}ge affects the contribution of ipsilateral brain regions
                      to movement kinematics},
      journal      = {Human brain mapping},
      volume       = {41},
      number       = {3},
      issn         = {1097-0193},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2019-05217},
      pages        = {640-655},
      year         = {2020},
      abstract     = {Healthy aging is accompanied by changes in brain activation
                      patterns in the motor system. In older subjects, unilateral
                      hand movements typically rely on increased recruitment of
                      ipsilateral frontoparietal areas. While the two central
                      concepts of aging‐related brain activity changes,
                      “Hemispheric Asymmetry Reduction in Older Adults”
                      (HAROLD), and “Posterior to Anterior Shift in Aging”
                      (PASA), have initially been suggested in the context of
                      cognitive tasks and were attributed to compensation, current
                      knowledge regarding the functional significance of increased
                      motor system activity remains scarce. We, therefore, used
                      online interference transcranial magnetic stimulation in
                      young and older subjects to investigate the role of key
                      regions of the ipsilateral frontoparietal cortex, that is,
                      (a) primary motor cortex (M1), (b) dorsal premotor cortex
                      (dPMC), and (c) anterior intraparietal sulcus (IPS) in the
                      control of hand movements of different motor demands. Our
                      data suggest a change of the functional roles of ipsilateral
                      brain areas in healthy age with a reduced relevance of
                      ipsilateral M1 and a shift of importance toward dPMC for
                      repetitive high‐frequency movements. These results support
                      the notion that mechanisms conceptualized in the models of
                      “PASA” and “HAROLD” also apply to the motor system.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31617272},
      UT           = {WOS:000490177900001},
      doi          = {10.1002/hbm.24829},
      url          = {https://juser.fz-juelich.de/record/865951},
}