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@ARTICLE{Hess:865958,
author = {Hess, Jonathan L and Tylee, Daniel S and Mattheisen, Manuel
and Consortium, Schizophrenia Working Group of the
Psychiatric Genomics and Research, Lundbeck Foundation
Initiative for Integrative Psychiatric and Børglum, Anders
D and Als, Thomas D and Grove, Jakob and Werge, Thomas and
Mortensen, Preben Bo and Mors, Ole and Nordentoft, Merete
and Hougaard, David M and Byberg-Grauholm, Jonas and
Bækvad-Hansen, Marie and Greenwood, Tiffany A and Tsuang,
Ming T and Curtis, David and Steinberg, Stacy and
Sigurdsson, Engilbert and Stefánsson, Hreinn and
Stefánsson, Kári and Edenberg, Howard J and Holmans, Peter
and Faraone, Stephen V and Glatt, Stephen J and Adolfsson,
Rolf and Agartz, Ingrid and Agerbo, Esben and Albus, Margot
and Alexander, Madeline and Amin, Farooq and Andreassen, Ole
A and Arranz, Maria J and Bacanu, Silviu A and Bakker,
Steven and Band, Gavin and Barroso, Ines and Begemann,
Martin and Bellenguez, Céline and Belliveau, Richard A and
Bender, Stephan and Bene, Judit and Bergen, Sarah E and
Bevilacqua, Elizabeth and Bigdeli, Tim B and Black, Donald W
and Blackburn, Hannah and Blackwell, Jenefer M and
Blackwood, Douglas H R and Bramon, Elvira and Brown, Matthew
A and Bruggeman, Richard and Buccola, Nancy G and Buckner,
Randy L and Bulik-Sullivan, Brendan and Bumpstead, Suzannah
J and Buxbaum, Joseph D and Byerley, William and Cahn,
Wiepke and Cai, Guiqing and Campion, Dominique and Cantor,
Rita M and Carr, Vaughan J and Carrera, Noa and Casas, Juan
P and Catts, Stanley V and Chambert, Kimberley D and Chan,
Ronald Y L and Chan, Raymond C K and Chen, Eric Y H and
Cheng, Wei and Cheung, Eric F C and Chong, Siow Ann and
Cichon, Sven and Cloninger, C Robert and Cohen, David and
Cohen, Nadine and Collier, David A and Cormican, Paul and
Corvin, Aiden and Craddock, Nick and Crespo-Facorro,
Benedicto and Crowley, James J and Daly, Mark J and Darvasi,
Ariel and Davidson, Michael and Davis, Kenneth L and
Degenhardt, Franziska and Del Favero, Jurgen and Deloukas,
Panos and Demontis, Ditte and Dikeos, Dimitris and Dinan,
Timothy and Djurovic, Srdjan and Domenici, Enrico and
Donnelly, Peter and Donohoe, Gary and Drapeau, Elodie and
Dronov, Serge and Duan, Jubao and Dudbridge, Frank and
Duncanson, Audrey and Durmishi, Naser and Edkins, Sarah and
Ehrenreich, Hannelore and Eichhammer, Peter and Eriksson,
Johan and Escott-Price, Valentina and Esko, Tõnu and
Essioux, Laurent and Fanous, Ayman H and Farh, Kai-How and
Farrell, Martilias S and Frank, Josef and Franke, Lude and
Freedman, Robert and Freeman, Colin and Freimer, Nelson B
and Friedl, Marion and Friedman, Joseph I and Fromer,
Menachem and Gejman, Pablo V and Genovese, Giulio and
Georgieva, Lyudmila and Giannoulatou, Eleni and Giegling,
Ina and Gill, Michael and Gillman, Matthew and
Giusti-Rodríguez, Paola and Godard, Stephanie and
Goldstein, Jacqueline I and Golimbet, Vera and Gopal,
Srihari and Gratten, Jacob and Gray, Emma and Gurling, Hugh
and Gwilliam, Rhian and de Haan, Lieuwe and Hall, Jeremy and
Hammer, Christian and Hammond, Naomi and Hamshere, Marian L
and Hansen, Mark and Hansen, Thomas and Haroutunian, Vahram
and Hartmann, Annette M and Hellenthal, Garrett and
Henskens, Frans A and Herms, Stefan and Hirschhorn, Joel N
and Hoffmann, Per and Hofman, Andrea and Hollegaard, Mads V
and Huang, Hailiang and Hultman, Christina M and Hunt, Sarah
E and Ikeda, Masashi and Iwata, Nakao and Iyegbe, Conrad and
Jablensky, Assen V and Jankowski, Janusz and Jayakumar,
Alagurevathi and Joa, Inge and Jönsson, Erik G and Julià,
Antonio and Kähler, Anna K and Kahn, René S and
Kalaydjieva, Luba and Karachanak-Yankova, Sena and
Karjalainen, Juha and Kavanagh, David and Keller, Matthew C
and Kendler, Kenneth S and Kennedy, James L and Khrunin,
Andrey and Kim, Yunjung and Kirov, George and Klovins, Janis
and Knight, Jo and Knowles, James A and Konte, Bettina and
Kucinskas, Vaidutis and Kucinskiene, Zita Ausrele and
Kuzelova-Ptackova, Hana and Langford, Cordelia and Laurent,
Claudine and Lawrie, Stephen and Lee, S Hong and Lee, Phil
and Lee, Jimmy and Legge, Sophie E and Lencz, Todd and
Lerer, Bernard and Levinson, Douglas F and Lewis, Cathryn M
and Li, Tao and Li, Qingqin S and Li, Miaoxin and Liang,
Kung-Yee and Liddle, Jennifer and Lieberman, Jeffrey and
Limborska, Svetlana and Lin, Kuang and Linszen, Don H and
Liu, Jianjun and Lönnqvist, Jouko and Loughland, Carmel M
and Lubinski, Jan and Macek, Milan and Magnusson, Patrik K E
and Maher, Brion S and Maier, Wolfgang and Malhotra, Anil K
and Mallet, Jacques and Markus, Hugh S and Marsal, Sara and
Mata, Ignacio and Mathew, Christopher G and Mattingsdal,
Morten and McCann, Owen T and McCarley, Robert W and
McCarroll, Steven A and McCarthy, Mark I and McDonald, Colm
and McIntosh, Andrew M and McQuillin, Andrew and Meier,
Sandra and Meijer, Carin J and Melegh, Bela and Melle,
Ingrid and Mesholam-Gately, Raquelle I and Metspalu, Andres
and Michie, Patricia T and Milani, Lili and Milanova, Vihra
and Mokrab, Younes and Moran, Jennifer L and Morris, Derek W
and Mowry, Bryan J and Müller-Myhsok, Bertram and Murphy,
Kieran C and Murray, Robin M and Myin-Germeys, Inez and
Neale, Benjamin M and Nelis, Mari and Nenadic, Igor and
Nertney, Deborah A and Nestadt, Gerald and Nicodemus,
Kristin K and Nikitina-Zake, Liene and Nisenbaum, Laura and
Nordin, Annelie and Nöthen, Markus M and O'Callaghan,
Eadbhard and O'Donovan, Michael C and O'Dushlaine, Colm and
O'Neill, F Anthony and Oh, Sang-Yun and Olincy, Ann and
Olsen, Line and Ophoff, Roel A and Van Os, Jim and Owen,
Michael J and Palmer, Colin N A and Palotie, Aarno and
Pantelis, Christos and Papadimitriou, George N and Papiol,
Sergi and Parkhomenko, Elena and Pato, Michele T and Pato,
Carlos N and Paunio, Tiina and Pearson, Richard and Cairns,
Murray J and DeLisi, Lynn E and Gershon, Elliot S and Kelly,
Brian J and Lam, Max and Norgren, Nina and Paciga, Sara A
and Tooney, Paul A and Wu, Jing Qin and
Pejovic-Milovancevic, Milica and Perkins, Diana O and Pers,
Tune H and Petryshen, Tracey L and Pietiläinen, Olli and
Pimm, Jonathan and Pirinen, Matti and Plomin, Robert and
Pocklington, Andrew J and Posthuma, Danielle and Potter,
Simon C and Powell, John and Price, Alkes and Pulver, Ann E
and Purcell, Shaun M and Quested, Digby and Rasmussen,
Henrik B and Rautanen, Anna and Ravindrarajah, Radhi and
Reichenberg, Abraham and Reimers, Mark A and Richards,
Alexander L and Ricketts, Michelle and Rietschel, Marcella
and Riley, Brien P and Ripke, Stephan and Roffman, Joshua L
and Roussos, Panos and Ruderfer, Douglas M and Rujescu, Dan
and Salomaa, Veikko and Sanders, Alan R and Sawcer, Stephen
J and Schall, Ulrich and Schubert, Christian R and Schulze,
Thomas G and Schwab, Sibylle G and Scolnick, Edward M and
Scott, Rodney J and Seidman, Larry J and Sham, Pak C and
Shi, Jianxin and Sigurdsson, Engilbert and Silagadze,
Teimuraz and Silverman, Jeremy M and Sim, Kang and Sklar,
Pamela and Slominsky, Petr and Smoller, Jordan W and So,
Hon-Cheong and Söderman, Erik and Spencer, Chris C A and
Clair, David St and Stahl, Eli A and Stogmann, Elisabeth and
Strange, Amy and Straub, Richard E and Strengman, Eric and
Strohmaier, Jana and Stroup, T Scott and Su, Zhan and
Subramaniam, Mythily and Sullivan, Patrick F and Suvisaari,
Jaana and Svrakic, Dragan M and Szatkiewicz, Jin P and
Tashakkori-Ghanbaria, Avazeh and Thirumalai, Srinivas and
Toncheva, Draga and Tosato, Sarah and Trembath, Richard C
and Veijola, Juha and Visscher, Peter M and Viswanathan,
Ananth C and Vukcevic, Damjan and Waddington, John and
Waller, Matthew and Walsh, Dermot and Walshe, Muriel and
Walters, James T R and Wang, Qiang and Wang, Dai and Webb,
Bradley T and Weinberger, Daniel R and Weisbrod, Matthias
and Weiser, Mark and Wendland, Jens R and Weston, Paul and
Whittaker, Pamela and Widaa, Sara and Wiersma, Durk and
Wildenauer, Dieter B and Williams, Stephanie and Williams,
Nigel M and Witt, Stephanie H and Wolen, Aaron R and Wong,
Emily H M and Wood, Nicholas W and Wormley, Brandon K and
Wray, Naomi R and Xi, Hualin Simon and Zai, Clement C and
Zheng, Xuebin and Zimprich, Fritz},
title = {{A} polygenic resilience score moderates the genetic risk
for schizophrenia},
journal = {Molecular psychiatry},
volume = {26},
issn = {1476-5578},
address = {London},
publisher = {Macmillan},
reportid = {FZJ-2019-05224},
pages = {800–815},
year = {2021},
abstract = {Based on the discovery by the Resilience Project (Chen R.
et al. Nat Biotechnol 34:531-538, 2016) of rare variants
that confer resistance to Mendelian disease, and protective
alleles for some complex diseases, we posited the existence
of genetic variants that promote resilience to highly
heritable polygenic disorders1,0 such as schizophrenia.
Resilience has been traditionally viewed as a psychological
construct, although our use of the term resilience refers to
a different construct that directly relates to the
Resilience Project, namely: heritable variation that
promotes resistance to disease by reducing the penetrance of
risk loci, wherein resilience and risk loci operate
orthogonal to one another. In this study, we established a
procedure to identify unaffected individuals with relatively
high polygenic risk for schizophrenia, and contrasted them
with risk-matched schizophrenia cases to generate the first
known 'polygenic resilience score' that represents the
additive contributions to SZ resistance by variants that are
distinct from risk loci. The resilience score was derived
from data compiled by the Psychiatric Genomics Consortium,
and replicated in three independent samples. This work
establishes a generalizable framework for finding resilience
variants for any complex, heritable disorder.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31492941},
UT = {WOS:000622346900008},
doi = {10.1038/s41380-019-0463-8},
url = {https://juser.fz-juelich.de/record/865958},
}
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