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@ARTICLE{Janiri:866113,
      author       = {Janiri, Delfina and Moser, Dominik A. and Doucet, Gaelle E.
                      and Luber, Maxwell J. and Rasgon, Alexander and Lee, Won Hee
                      and Murrough, James W. and Sani, Gabriele and Eickhoff,
                      Simon B. and Frangou, Sophia},
      title        = {{S}hared {N}eural {P}henotypes for {M}ood and {A}nxiety
                      {D}isorders},
      journal      = {JAMA psychiatry},
      volume       = {77},
      number       = {2},
      issn         = {2168-622X},
      address      = {Chicago, Ill.},
      publisher    = {JAMA},
      reportid     = {FZJ-2019-05332},
      pages        = {172-179},
      year         = {2020},
      note         = {This work was supported in part through the computational
                      resources and staff expertise provided by Scientific
                      Computing at the Icahn School of Medicine at Mount Sinai.
                      Drs Frangou and Doucet received support from the National
                      Institute of Mental Health (R01-MH104284 and R01-MH116147).
                      Dr Eickhoff received support by the Deutsche
                      Forschungsgemeinschaft (DFG, EI 816/11-1), the National
                      Institute of Mental Health (R01-MH074457), and the European
                      Union’s Horizon 2020 Research and Innovation Programme
                      under Grant Agreements 720270 (HBP SGA1) and 785907 (HBP
                      SGA2).},
      abstract     = {Importance:Major depressive disorder, bipolar disorder,
                      posttraumatic stress disorder, and anxiety disorders are
                      highly comorbid and have shared clinical features. It is not
                      yet known whether their clinical overlap is reflected at the
                      neurobiological level.Objective:To detect transdiagnostic
                      convergence in abnormalities in task-related brain
                      activation.Data Source:Task-related functional magnetic
                      resonance imaging articles published in PubMed, Web of
                      Science, and Google Scholar during the last decade comparing
                      control individuals with patients with mood, posttraumatic
                      stress, and anxiety disorders were examined.Study
                      Selection:Following Preferred Reporting Items for Systematic
                      Reviews and Meta-analyses reporting guidelines, articles
                      were selected if they reported stereotactic coordinates of
                      whole-brain-based activation differences between adult
                      patients and control individuals.Data Extraction and
                      Synthesis:Coordinates of case-control differences coded by
                      diagnosis and by cognitive domain based on the research
                      domain criteria were analyzed using activation likelihood
                      estimation.Main Outcomes and Measures:Identification of
                      transdiagnostic clusters of aberrant activation and
                      quantification of the contribution of diagnosis and
                      cognitive domain to each cluster.Results:A total of 367
                      experiments (major depressive disorder, 149; bipolar
                      disorder, 103; posttraumatic stress disorder, 55; and
                      anxiety disorders, 60) were included comprising observations
                      from 4507 patients and 4755 control individuals. Three
                      right-sided clusters of hypoactivation were identified
                      centered in the inferior prefrontal cortex/insula (volume,
                      2120 mm3), the inferior parietal lobule (volume, 1224 mm3),
                      and the putamen (volume, 888 mm3); diagnostic differences
                      were noted only in the putamen (χ23 = 8.66;
                      P = .03), where hypoactivation was more likely in
                      bipolar disorder (percentage $contribution = 72.17\%).$
                      Tasks associated with cognitive systems made the largest
                      contribution to each cluster (percentage contributions
                      $>29\%).$ Clusters of hyperactivation could only be detected
                      using a less stringent threshold. These were centered in the
                      perigenual/dorsal anterior cingulate cortex (volume, 2208
                      mm3), the left amygdala/parahippocampal gyrus (volume, 2008
                      mm3), and the left thalamus (volume, 1904 mm3). No
                      diagnostic differences were observed (χ23 < 3.06;
                      P > .38), while tasks associated with negative valence
                      systems made the largest contribution to each cluster
                      (percentage contributions $>49\%).$ All findings were robust
                      to the moderator effects of age, sex, and magnetic field
                      strength of the scanner and medication.Conclusions and
                      Relevance:In mood disorders, posttraumatic stress disorder,
                      and anxiety disorders, the most consistent transdiagnostic
                      abnormalities in task-related brain activity converge in
                      regions that are primarily associated with inhibitory
                      control and salience processing. Targeting these shared
                      neural phenotypes could potentially mitigate the risk of
                      affective morbidity in the general population and improve
                      outcomes in clinical populations.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {574 - Theory, modelling and simulation (POF3-574) / HBP
                      SGA2 - Human Brain Project Specific Grant Agreement 2
                      (785907)},
      pid          = {G:(DE-HGF)POF3-574 / G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31664439},
      UT           = {WOS:000512049000012},
      doi          = {10.1001/jamapsychiatry.2019.3351},
      url          = {https://juser.fz-juelich.de/record/866113},
}