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@ARTICLE{Beroz:866148,
      author       = {Beroz, Farzan and Yan, Jing and Meir, Yigal and Sabass,
                      Benedikt and Stone, Howard A. and Bassler, Bonnie L. and
                      Wingreen, Ned S.},
      title        = {{V}erticalization of bacterial biofilms},
      journal      = {Nature physics},
      volume       = {14},
      number       = {9},
      issn         = {1745-2481},
      address      = {Basingstoke},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2019-05344},
      pages        = {954 - 960},
      year         = {2018},
      abstract     = {Biofilms are communities of bacteria adhered to surfaces.
                      Recently, biofilms of rod-shaped bacteria were observed at
                      single-cell resolution and shown to develop from a
                      disordered, two-dimensional layer of founder cells into a
                      three-dimensional structure with a vertically aligned core.
                      Here, we elucidate the physical mechanism underpinning this
                      transition using a combination of agent-based and continuum
                      modelling. We find that verticalization proceeds through a
                      series of localized mechanical instabilities on the cellular
                      scale. For short cells, these instabilities are primarily
                      triggered by cell division, whereas long cells are more
                      likely to be peeled off the surface by nearby vertical
                      cells, creating an ‘inverse domino effect’. The
                      interplay between cell growth and cell verticalization gives
                      rise to an exotic mechanical state in which the effective
                      surface pressure becomes constant throughout the growing
                      core of the biofilm surface layer. This dynamical
                      isobaricity determines the expansion speed of a biofilm
                      cluster and thereby governs how cells access the third
                      dimension. In particular, theory predicts that a longer
                      average cell length yields more rapidly expanding, flatter
                      biofilms. We experimentally show that such changes in
                      biofilm development occur by exploiting chemicals that
                      modulate cell length},
      cin          = {ICS-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30906420},
      UT           = {WOS:000443584000029},
      doi          = {10.1038/s41567-018-0170-4},
      url          = {https://juser.fz-juelich.de/record/866148},
}