TY  - JOUR
AU  - Grodzinsky, Yosef
AU  - Deschamps, Isabelle
AU  - Pieperhoff, Peter
AU  - Iannilli, Francesca
AU  - Agmon, Galit
AU  - Loewenstein, Yonatan
AU  - Amunts, Katrin
TI  - Logical negation mapped onto the brain
JO  - Brain structure & function
VL  - 225
SN  - 1863-2661
CY  - Heidelberg
PB  - Springer
M1  - FZJ-2019-05468
SP  - 19-31
PY  - 2020
AB  - High-level cognitive capacities that serve communication, reasoning, and calculation are essential for finding our way in the world. But whether and to what extent these complex behaviors share the same neuronal substrate are still unresolved questions. The present study separated the aspects of logic from language and numerosity—mental faculties whose distinctness has been debated for centuries—and identified a new cytoarchitectonic area as correlate for an operation involving logical negation. A novel experimental paradigm that was implemented here in an RT/fMRI study showed a single cluster of activity that pertains to logical negation. It was distinct from clusters that were activated by numerical comparison and from the traditional language regions. The localization of this cluster was described by a newly identified cytoarchitectonic area in the left anterior insula, ventro-medial to Broca’s region. We provide evidence for the congruence between the histologically and functionally defined regions on multiple measures. Its position in the left anterior insula suggests that it functions as a mediator between language and reasoning areas.
LB  - PUB:(DE-HGF)16
C6  - pmid:31680213
UR  - <Go to ISI:>//WOS:000493786300001
DO  - DOI:10.1007/s00429-019-01975-w
UR  - https://juser.fz-juelich.de/record/866309
ER  -