%0 Journal Article
%A Yang, Danqing
%A Günter, Robert
%A Qi, Guanxiao
%A Radnikow, Gabriele
%A Feldmeyer, Dirk
%T Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits Is Cooperative and Cell-Specific
%J Cerebral cortex
%V 30
%N 6
%@ 1047-3211
%C Oxford
%I Oxford Univ. Press
%M FZJ-2019-05569
%P 3528–3542
%D 2020
%X Acetylcholine (ACh) is known to regulate cortical activity during different behavioral states, for example, wakefulness and attention. Here we show a differential expression of muscarinic ACh receptors (mAChRs) and nicotinic ACh receptors (nAChRs) in different layer 6A (L6A) pyramidal cell (PC) types of somatosensory cortex. At low concentrations, ACh induced a persistent hyperpolarization in corticocortical (CC) but a depolarization in corticothalamic (CT) L6A PCs via M 4 and M1 mAChRs, respectively. At ~ 1 mM, ACh depolarized exclusively CT PCs via α4β2 subunit-containing nAChRs without affecting CC PCs. Miniature EPSC frequency in CC PCs was decreased by ACh but increased in CT PCs. In synaptic connections with a presynaptic CC PC, glutamate release was suppressed via M4 mAChR activation but enhanced by nAChRs via α4β2 nAChRs when the presynaptic neuron was a CT PC. Thus, in L6A, the interaction of mAChRs and nAChRs results in an altered excitability and synaptic release, effectively strengthening CT output while weakening CC synaptic signaling.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 32026946
%U <Go to ISI:>//WOS:000535911100006
%R 10.1093/cercor/bhz324
%U https://juser.fz-juelich.de/record/866422