TY  - JOUR
AU  - Yang, Danqing
AU  - Günter, Robert
AU  - Qi, Guanxiao
AU  - Radnikow, Gabriele
AU  - Feldmeyer, Dirk
TI  - Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits Is Cooperative and Cell-Specific
JO  - Cerebral cortex
VL  - 30
IS  - 6
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2019-05569
SP  - 3528–3542
PY  - 2020
AB  - Acetylcholine (ACh) is known to regulate cortical activity during different behavioral states, for example, wakefulness and attention. Here we show a differential expression of muscarinic ACh receptors (mAChRs) and nicotinic ACh receptors (nAChRs) in different layer 6A (L6A) pyramidal cell (PC) types of somatosensory cortex. At low concentrations, ACh induced a persistent hyperpolarization in corticocortical (CC) but a depolarization in corticothalamic (CT) L6A PCs via M 4 and M1 mAChRs, respectively. At ~ 1 mM, ACh depolarized exclusively CT PCs via α4β2 subunit-containing nAChRs without affecting CC PCs. Miniature EPSC frequency in CC PCs was decreased by ACh but increased in CT PCs. In synaptic connections with a presynaptic CC PC, glutamate release was suppressed via M4 mAChR activation but enhanced by nAChRs via α4β2 nAChRs when the presynaptic neuron was a CT PC. Thus, in L6A, the interaction of mAChRs and nAChRs results in an altered excitability and synaptic release, effectively strengthening CT output while weakening CC synaptic signaling.
LB  - PUB:(DE-HGF)16
C6  - 32026946
UR  - <Go to ISI:>//WOS:000535911100006
DO  - DOI:10.1093/cercor/bhz324
UR  - https://juser.fz-juelich.de/record/866422
ER  -