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@ARTICLE{Liao:866638,
      author       = {Liao, Yupeng and Lechea, Nazim and Magill, Arthur W. and
                      Worthoff, Wieland A. and Gras, Vincent and Shah, N. J.},
      title        = {{C}orrelation of quantitative conductivity mapping and
                      total tissue sodium concentration at 3{T}/4{T}},
      journal      = {Magnetic resonance in medicine},
      volume       = {82},
      number       = {4},
      issn         = {1522-2594},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2019-05717},
      pages        = {1518 - 1526},
      year         = {2019},
      abstract     = {PurposeTo investigate the correlation between electrical
                      conductivity and sodium concentration, both measured in
                      vivo, in the human brain.MethodsConductivity measurements
                      were performed on samples with different sodium (Na+) and
                      agarose concentrations using a dielectric probe, and the
                      correlation between conductivity and Na+ content was
                      evaluated. Subsequently, brain conductivity and total Na+
                      content maps were measured in 8 healthy subjects using
                      phase‐based MREPT and sodium MRI, respectively. After
                      co‐registration and spatial normalization to the 1 mm 152
                      MNI brain atlas, the relationship between conductivity and
                      tissue sodium concentration (TSC) was examined within
                      different brain regions.ResultsThe conductivities of agarose
                      gels increased linearly with NaCl concentration, while
                      remaining almost independent of agarose content. When
                      measured in healthy subjects, conductivities showed positive
                      correlation with total tissue sodium concentration (R =
                      0.39, P < 0.005). The same trend was found in gray matter (R
                      = 0.36, P < 0.005) and in white matter (R = 0.28, P <
                      0.05).ConclusionTissue conductivity shows a positive
                      correlation with total sodium concentration. Conductivity
                      might serve as a novel technique to visualize the total
                      tissue electrolyte concentration, although refinements in
                      the consideration of e.g., tissue water content, would be
                      necessary to improve the quantitative value.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31095776},
      UT           = {WOS:000483917000024},
      doi          = {10.1002/mrm.27787},
      url          = {https://juser.fz-juelich.de/record/866638},
}