Gast ::
| Hauptseite > Publikationsdatenbank > Cerebral water content mapping in cirrhosis patients with and without manifest HE > print |
| Hauptseite > Publikationsdatenbank > Cerebral water content mapping in cirrhosis patients with and without manifest HE > print |
| 001 | 866641 | ||
| 005 | 20210130003550.0 | ||
| 024 | 7 | _ | |a 10.1007/s11011-019-00427-y |2 doi |
| 024 | 7 | _ | |a 0885-7490 |2 ISSN |
| 024 | 7 | _ | |a 1573-7365 |2 ISSN |
| 024 | 7 | _ | |a pmid:31089866 |2 pmid |
| 024 | 7 | _ | |a WOS:000475697800012 |2 WOS |
| 024 | 7 | _ | |a altmetric:60656393 |2 altmetric |
| 037 | _ | _ | |a FZJ-2019-05720 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Winterdahl, Michael |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Cerebral water content mapping in cirrhosis patients with and without manifest HE |
| 260 | _ | _ | |a Dordrecht [u.a.] |c 2019 |b Springer Science + Business Media B.V |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1574406861_25333 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Hepatic encephalopathy (HE) is a frequent and debilitating complication of cirrhosis and its pathogenesis is not definitively clarified. Recent hypotheses focus on the possible existence of low-grade cerebral edema due to accumulation of osmolytes secondary to hyperammonemia. In the present study we investigated increases in cerebral water content by a novel magnetic resonance impedance (MRI) technique in cirrhosis patients with and without clinically manifest HE. We used a 3 T MRI technique for quantitative cerebral water content mapping in nine cirrhosis patients with an episode of overt HE, ten cirrhosis patients who never suffered from HE, and ten healthy aged-matched controls. We tested for differences between groups by statistical non-parametric mapping (SnPM) for a voxel-based spatial evaluation. The patients with HE had significantly higher water content in white matter than the cirrhosis patients (0.6%), who in turn, had significantly higher content than the controls (1.7%). Although the global gray matter water content did not differ between the groups, the patients with HE had markedly higher thalamic water content than patients who never experienced HE (6.0% higher). We found increased white matter water content in cirrhosis patients, predominantly in those with manifest HE. This confirms the presence of increasing degrees of low-grade edema with exacerbation of pathology. The thalamic edema in manifest HE may lead to compromised basal ganglia-thalamo-cortical circuits, in accordance with the major clinical symptoms of HE. The identification of the thalamus as particularly inflicted in manifest HE is potentially relevant to the pathophysiology of HE. |
| 536 | _ | _ | |a 573 - Neuroimaging (POF3-573) |0 G:(DE-HGF)POF3-573 |c POF3-573 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a Abbas, Zaheer |0 P:(DE-Juel1)140186 |b 1 |
| 700 | 1 | _ | |a Noer, Ove |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Thomsen, Karen Louise |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Gras, Vincent |0 P:(DE-Juel1)131765 |b 4 |
| 700 | 1 | _ | |a Nahimi, Adjmal |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Vilstrup, Hendrik |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Shah, Nadim Joni |0 P:(DE-Juel1)131794 |b 7 |
| 700 | 1 | _ | |a Dam, Gitte |0 0000-0003-3526-0171 |b 8 |e Corresponding author |
| 773 | _ | _ | |a 10.1007/s11011-019-00427-y |g Vol. 34, no. 4, p. 1071 - 1076 |0 PERI:(DE-600)2018067-6 |n 4 |p 1071 - 1076 |t Metabolic brain disease |v 34 |y 2019 |x 1573-7365 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/866641/files/Winterdahl2019_Article_CerebralWaterContentMappingInC.pdf |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/866641/files/Winterdahl2019_Article_CerebralWaterContentMappingInC.pdf?subformat=pdfa |x pdfa |y Restricted |
| 909 | C | O | |o oai:juser.fz-juelich.de:866641 |p VDB |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)140186 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 7 |6 P:(DE-Juel1)131794 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Decoding the Human Brain |1 G:(DE-HGF)POF3-570 |0 G:(DE-HGF)POF3-573 |2 G:(DE-HGF)POF3-500 |v Neuroimaging |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2019 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b METAB BRAIN DIS : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-4-20090406 |k INM-4 |l Physik der Medizinischen Bildgebung |x 0 |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-11-20170113 |k INM-11 |l Jara-Institut Quantum Information |x 1 |
| 920 | 1 | _ | |0 I:(DE-82)080010_20140620 |k JARA-BRAIN |l JARA-BRAIN |x 2 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)INM-4-20090406 |
| 980 | _ | _ | |a I:(DE-Juel1)INM-11-20170113 |
| 980 | _ | _ | |a I:(DE-82)080010_20140620 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|