% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Sichtermann:866646,
      author       = {Sichtermann, T. and Furtmann, J. K. and Dekeyzer, S. and
                      Gilmour, G. and Oros-Peusquens, Ana-Maria and Bach, J. P.
                      and Wiesmann, M. and Shah, N. J. and Nikoubashman, Omid},
      title        = {{I}ncreased {W}ater {C}ontent in {P}eriventricular {C}aps
                      in {P}atients without {A}cute {H}ydrocephalus},
      journal      = {American journal of neuroradiology},
      volume       = {40},
      number       = {5},
      issn         = {1936-959X},
      address      = {Oak Brook, Ill.},
      publisher    = {Soc.},
      reportid     = {FZJ-2019-05725},
      pages        = {784 - 787},
      year         = {2019},
      abstract     = {BACKGROUND AND PURPOSE: Periventricular caps are a common
                      finding on MR imaging and are believed to reflect focally
                      increased interstitial water content due to dysfunctional
                      transependymal transportation rather than ischemic-gliotic
                      changes. We compared the quantitative water content of
                      periventricular caps and microvascular white matter lesions,
                      hypothesizing that periventricular caps associated with
                      increased interstitial fluid content display higher water
                      content than white matter lesions and are therefore
                      differentiable from microvascular white matter lesions by
                      measurement of the water content.MATERIALS AND METHODS: In a
                      prospective study, we compared the water content of
                      periventricular caps and white matter lesions in 50 patients
                      using a quantitative multiple-echo, gradient-echo MR imaging
                      water-mapping sequence.RESULTS: The water content of
                      periventricular caps was significantly higher than that of
                      white matter lesions (P = .002). Compared with normal white
                      matter, the mean water content of periventricular caps was
                      $17\%$ ± $5\%$ higher and the mean water content of white
                      matter lesions was $11\%$ ± $4\%$ higher. Receiver
                      operating characteristic analysis revealed that areas in
                      which water content was $15\%$ higher compared with normal
                      white matter correspond to periventricular caps rather than
                      white matter lesions, with a specificity of $93\%$ and a
                      sensitivity of $60\%$ (P < .001). There was no significant
                      correlation between the water content of periventricular
                      caps and whole-brain volume (P = .275), white matter volume
                      (P = .243), gray matter volume (P = .548), lateral ventricle
                      volume (P = .800), white matter lesion volume (P = .081),
                      periventricular cap volume (P = .081), and age (P =
                      .224).CONCLUSIONS: Quantitative MR imaging allows
                      differentiation between periventricular caps and white
                      matter lesions. Water content quantification of
                      T2-hyperintense lesions may be a useful additional tool for
                      the characterization and differentiation of T2-hyperintense
                      diseases.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30975653},
      UT           = {WOS:000468119900009},
      doi          = {10.3174/ajnr.A6033},
      url          = {https://juser.fz-juelich.de/record/866646},
}